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The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway

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2010

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http://nbn-resolving.de/urn:nbn:de:bsz:352-148156
DOI (zitierfähiger Link)
https://doi.org/10.1002/dvdy.22060
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Biologie: Publikationen
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Developmental Dynamics. 2010, 239(1), pp. NA-NA. ISSN 1058-8388. eISSN 1097-0177. Available under: doi: 10.1002/dvdy.22060

Zusammenfassung

Signaling by the Wingless morphogen (a member of the Wnt family of secreted glycoproteins) is required for the proper development of appendages in Drosophila. Overexpression of Axin, a negative regulator of Wnt signaling, leads to severe defects in Drosophila wing growth and patterning (the affected wing is shown in a green pseudocolor, compared to a wild-type wing in pink). The inhibitory activity of Axin can be suppressed by co-expression of the GTP-binding protein Gαo, leading to a partial rescue in wing development (yellow). Gαo physically binds the RGS domain of Axin and recruits Axin it to the plasma membrane, antagonizing the Axin-based destruction complex.

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570 Biowissenschaften, Biologie

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Wnt, Frizzled, G proteins, Axin, Dishevelled, Drosophila

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ISO 690EGGER-ADAM, Diane, Vladimir L. KATANAEV, 2010. The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway. In: Developmental Dynamics. 2010, 239(1), pp. NA-NA. ISSN 1058-8388. eISSN 1097-0177. Available under: doi: 10.1002/dvdy.22060
BibTex
@article{EggerAdam2010-01trime-14815,
  year={2010},
  doi={10.1002/dvdy.22060},
  title={The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway},
  number={1},
  volume={239},
  issn={1058-8388},
  journal={Developmental Dynamics},
  pages={NA--NA},
  author={Egger-Adam, Diane and Katanaev, Vladimir L.}
}
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    <dcterms:abstract xml:lang="eng">Signaling by the Wingless morphogen (a member of the Wnt family of secreted glycoproteins) is required for the proper development of appendages in Drosophila. Overexpression of Axin, a negative regulator of Wnt signaling, leads to severe defects in Drosophila wing growth and patterning (the affected wing is shown in a green pseudocolor, compared to a wild-type wing in pink). The inhibitory activity of Axin can be suppressed by co-expression of the GTP-binding protein Gαo, leading to a partial rescue in wing development (yellow). Gαo physically binds the RGS domain of Axin and recruits Axin it to the plasma membrane, antagonizing the Axin-based destruction complex.</dcterms:abstract>
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