Neural substrates of pleiotropic action of genetic variation in COMT : a meta-analysis
| dc.contributor.author | Mier, Daniela | |
| dc.contributor.author | Kirsch, Peter | |
| dc.contributor.author | Meyer-Lindenberg, Andreas | |
| dc.date.accessioned | 2019-04-17T11:36:08Z | |
| dc.date.available | 2019-04-17T11:36:08Z | |
| dc.date.issued | 2010-09 | eng |
| dc.description.abstract | Genetic variation in catechol-O-methyltransferase (COMT), encoding an enzyme critical for prefrontal dopamine flux, has been studied extensively using both behavioral and neuroimaging methods. In behavior, pleiotropic action of a functional Val158Met (rs4680) polymorphism on executive cognition and emotional stability has been described and proposed to be of evolutionary significance (the 'warrior/worrier' hypothesis). We conducted a meta-analysis of all available neuroimaging studies of rs4680 to investigate the evidence for a neural substrate of this behavioral pleiotropy. We show significant association between the COMT genotype and prefrontal activation, with large (d=0.73) effect size without evidence for publication bias. Strong and opposing effects were found for executive cognition paradigms (favoring Met allele carriers) and emotional paradigms (favoring Val), providing meta-analytical evidence for a neural substrate for the pleiotropic behavioral effects of COMT genetic variation and validating the use of intermediate phenotypes as a method to bridge between genes and behavior. | eng |
| dc.description.version | published | eng |
| dc.identifier.doi | 10.1038/mp.2009.36 | eng |
| dc.identifier.pmid | 19417742 | eng |
| dc.identifier.uri | https://kops.uni-konstanz.de/handle/123456789/45669 | |
| dc.language.iso | eng | eng |
| dc.subject.ddc | 150 | eng |
| dc.title | Neural substrates of pleiotropic action of genetic variation in COMT : a meta-analysis | eng |
| dc.type | JOURNAL_ARTICLE | eng |
| dspace.entity.type | Publication | |
| kops.citation.bibtex | @article{Mier2010-09Neura-45669,
year={2010},
doi={10.1038/mp.2009.36},
title={Neural substrates of pleiotropic action of genetic variation in COMT : a meta-analysis},
volume={15},
issn={1359-4184},
journal={Molecular Psychiatry},
pages={918--927},
author={Mier, Daniela and Kirsch, Peter and Meyer-Lindenberg, Andreas}
} | |
| kops.citation.iso690 | MIER, Daniela, Peter KIRSCH, Andreas MEYER-LINDENBERG, 2010. Neural substrates of pleiotropic action of genetic variation in COMT : a meta-analysis. In: Molecular Psychiatry. 2010, 15, pp. 918-927. ISSN 1359-4184. eISSN 1476-5578. Available under: doi: 10.1038/mp.2009.36 | deu |
| kops.citation.iso690 | MIER, Daniela, Peter KIRSCH, Andreas MEYER-LINDENBERG, 2010. Neural substrates of pleiotropic action of genetic variation in COMT : a meta-analysis. In: Molecular Psychiatry. 2010, 15, pp. 918-927. ISSN 1359-4184. eISSN 1476-5578. Available under: doi: 10.1038/mp.2009.36 | eng |
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| kops.sourcefield.plain | Molecular Psychiatry. 2010, 15, pp. 918-927. ISSN 1359-4184. eISSN 1476-5578. Available under: doi: 10.1038/mp.2009.36 | eng |
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