Neural substrates of pleiotropic action of genetic variation in COMT : a meta-analysis

dc.contributor.authorMier, Daniela
dc.contributor.authorKirsch, Peter
dc.contributor.authorMeyer-Lindenberg, Andreas
dc.date.accessioned2019-04-17T11:36:08Z
dc.date.available2019-04-17T11:36:08Z
dc.date.issued2010-09eng
dc.description.abstractGenetic variation in catechol-O-methyltransferase (COMT), encoding an enzyme critical for prefrontal dopamine flux, has been studied extensively using both behavioral and neuroimaging methods. In behavior, pleiotropic action of a functional Val158Met (rs4680) polymorphism on executive cognition and emotional stability has been described and proposed to be of evolutionary significance (the 'warrior/worrier' hypothesis). We conducted a meta-analysis of all available neuroimaging studies of rs4680 to investigate the evidence for a neural substrate of this behavioral pleiotropy. We show significant association between the COMT genotype and prefrontal activation, with large (d=0.73) effect size without evidence for publication bias. Strong and opposing effects were found for executive cognition paradigms (favoring Met allele carriers) and emotional paradigms (favoring Val), providing meta-analytical evidence for a neural substrate for the pleiotropic behavioral effects of COMT genetic variation and validating the use of intermediate phenotypes as a method to bridge between genes and behavior.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1038/mp.2009.36eng
dc.identifier.pmid19417742eng
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/45669
dc.language.isoengeng
dc.subject.ddc150eng
dc.titleNeural substrates of pleiotropic action of genetic variation in COMT : a meta-analysiseng
dc.typeJOURNAL_ARTICLEeng
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@article{Mier2010-09Neura-45669,
  year={2010},
  doi={10.1038/mp.2009.36},
  title={Neural substrates of pleiotropic action of genetic variation in COMT : a meta-analysis},
  volume={15},
  issn={1359-4184},
  journal={Molecular Psychiatry},
  pages={918--927},
  author={Mier, Daniela and Kirsch, Peter and Meyer-Lindenberg, Andreas}
}
kops.citation.iso690MIER, Daniela, Peter KIRSCH, Andreas MEYER-LINDENBERG, 2010. Neural substrates of pleiotropic action of genetic variation in COMT : a meta-analysis. In: Molecular Psychiatry. 2010, 15, pp. 918-927. ISSN 1359-4184. eISSN 1476-5578. Available under: doi: 10.1038/mp.2009.36deu
kops.citation.iso690MIER, Daniela, Peter KIRSCH, Andreas MEYER-LINDENBERG, 2010. Neural substrates of pleiotropic action of genetic variation in COMT : a meta-analysis. In: Molecular Psychiatry. 2010, 15, pp. 918-927. ISSN 1359-4184. eISSN 1476-5578. Available under: doi: 10.1038/mp.2009.36eng
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kops.sourcefieldMolecular Psychiatry. 2010, <b>15</b>, pp. 918-927. ISSN 1359-4184. eISSN 1476-5578. Available under: doi: 10.1038/mp.2009.36deu
kops.sourcefield.plainMolecular Psychiatry. 2010, 15, pp. 918-927. ISSN 1359-4184. eISSN 1476-5578. Available under: doi: 10.1038/mp.2009.36deu
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