Publikation:

Nitric Oxide Inhibits Execution of Apoptosis at Two Distinct ATP-Dependent Steps Upstream and Downstream of Mitochondrial Cytochrome c Release

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Leist_M_Biochem_Biophys_Res_Commun_1999.pdf
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Datum

1999

Autor:innen

Single, Barbara
Fava, Eugenio
Simon, Bernadett

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http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-81464
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https://doi.org/10.1006/bbrc.1999.0491
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Published

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Biochemical and Biophysical Research Communications. 1999, 258(1), pp. 215-221. ISSN 0006-291X. Available under: doi: 10.1006/bbrc.1999.0491

Zusammenfassung

The endogenous mediator nitric oxide (NO) blocked apoptosis of Jurkat cells elicited by staurosporine, anti-CD95 or chemotherapeutics, and switched death to necrosis. The switch in the mode of cell death was dependent on the ATP loss elicited by NO. This affected two distinct steps of the apop· totic cascade. First, the release of cytochrome c from mitochondria was delayed by NO. Second, processing of procaspases-317 to the active proteases was prevented even after cytochrome c had been released. Thus, NO interferes with execution steps of apoptosis both upstream and downstream of cytochrome c release.

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570 Biowissenschaften, Biologie

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ISO 690LEIST, Marcel, Barbara SINGLE, Heike NAUMANN, Eugenio FAVA, Bernadett SIMON, Simone KÜHNLE, Pierluigi NICOTERA, 1999. Nitric Oxide Inhibits Execution of Apoptosis at Two Distinct ATP-Dependent Steps Upstream and Downstream of Mitochondrial Cytochrome c Release. In: Biochemical and Biophysical Research Communications. 1999, 258(1), pp. 215-221. ISSN 0006-291X. Available under: doi: 10.1006/bbrc.1999.0491
BibTex
@article{Leist1999Nitri-8523,
  year={1999},
  doi={10.1006/bbrc.1999.0491},
  title={Nitric Oxide Inhibits Execution of Apoptosis at Two Distinct ATP-Dependent Steps Upstream and Downstream of Mitochondrial Cytochrome c Release},
  number={1},
  volume={258},
  issn={0006-291X},
  journal={Biochemical and Biophysical Research Communications},
  pages={215--221},
  author={Leist, Marcel and Single, Barbara and Naumann, Heike and Fava, Eugenio and Simon, Bernadett and Kühnle, Simone and Nicotera, Pierluigi}
}
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