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Structural correlations and melting of B-DNA fibers

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2011

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Wildes, Andrew
Valle-Orero, Jessica
Cuesta-López, Santiago
Garden, Jean-Luc
Peyrard, Michel

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https://doi.org/10.1103/PhysRevE.83.061923
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Physical Review E. American Physical Society (APS). 2011, 83(6), 061923. ISSN 1539-3755. eISSN 1550-2376. Available under: doi: 10.1103/PhysRevE.83.061923

Zusammenfassung

Despite numerous attempts, understanding the thermal denaturation of DNA is still a challenge due to the lack of structural data on the transition since standard experimental approaches to DNA melting are made in solution and do not provide spatial information. We report a measurement using neutron scattering from oriented DNA fibers to determine the size of the regions that stay in the double-helix conformation as the melting temperature is approached from below. A Bragg peak from the B form of DNA is observed as a function of temperature and its width and integrated intensity are measured. These results, complemented by a differential calorimetry study of the melting of B-DNA fibers as well as electrophoresis and optical observation data, are analyzed in terms of a one-dimensional mesoscopic model of DNA.

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ISO 690WILDES, Andrew, Nikos THEODORAKOPOULOS, Jessica VALLE-ORERO, Santiago CUESTA-LÓPEZ, Jean-Luc GARDEN, Michel PEYRARD, 2011. Structural correlations and melting of B-DNA fibers. In: Physical Review E. American Physical Society (APS). 2011, 83(6), 061923. ISSN 1539-3755. eISSN 1550-2376. Available under: doi: 10.1103/PhysRevE.83.061923
BibTex
@article{Wildes2011-06Struc-50375,
  year={2011},
  doi={10.1103/PhysRevE.83.061923},
  title={Structural correlations and melting of B-DNA fibers},
  number={6},
  volume={83},
  issn={1539-3755},
  journal={Physical Review E},
  author={Wildes, Andrew and Theodorakopoulos, Nikos and Valle-Orero, Jessica and Cuesta-López, Santiago and Garden, Jean-Luc and Peyrard, Michel},
  note={Article Number: 061923}
}
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