Publikation: Role of Melanoma Inhibitor of Apoptosis (ML-IAP) Protein, a Member of the Baculoviral IAP Repeat (BIR) Domain Family, in the Regulation of C-RAF Kinase and Cell Migration
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2012
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The Journal of Biological Chemistry : JBC. 2012, 287(34), pp. 28445-28455. ISSN 0021-9258. eISSN 1083-351X. Available under: doi: 10.1074/jbc.M112.341297
Zusammenfassung
Inhibitor of apoptosis (IAPs) proteins are characterized by the presence of evolutionarily conserved baculoviral inhibitor of apoptosis repeat (BIR) domains, predominantly known for their role in inhibiting caspases and, thereby, apoptosis. We have shown previously that multi-BIR domain-containing IAPs, cellular IAPs, and X-linked IAP can control tumor cell migration by directly regulating the protein stability of C-RAF kinase. Here, we extend our observations to a single BIR domain containing IAP family member melanoma-IAP (ML-IAP). We show that ML-IAP can directly bind to C-RAF and that ML-IAP depletion leads to an increase in C-RAF protein levels, MAPK activation, and cell migration in melanoma cells. Thus, our results unveil a thus far unknown role for ML-IAP in controlling C-RAF stability and cell migration.
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570 Biowissenschaften, Biologie
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OBEROI-KHANUJA, Tripat Kaur, Christiaan KARREMAN, Sarit LARISCH, Ulf R. RAPP, Krishnaraj RAJALINGAM, 2012. Role of Melanoma Inhibitor of Apoptosis (ML-IAP) Protein, a Member of the Baculoviral IAP Repeat (BIR) Domain Family, in the Regulation of C-RAF Kinase and Cell Migration. In: The Journal of Biological Chemistry : JBC. 2012, 287(34), pp. 28445-28455. ISSN 0021-9258. eISSN 1083-351X. Available under: doi: 10.1074/jbc.M112.341297BibTex
@article{OberoiKhanuja2012-08-17Melan-38708,
year={2012},
doi={10.1074/jbc.M112.341297},
title={Role of Melanoma Inhibitor of Apoptosis (ML-IAP) Protein, a Member of the Baculoviral IAP Repeat (BIR) Domain Family, in the Regulation of C-RAF Kinase and Cell Migration},
number={34},
volume={287},
issn={0021-9258},
journal={The Journal of Biological Chemistry : JBC},
pages={28445--28455},
author={Oberoi-Khanuja, Tripat Kaur and Karreman, Christiaan and Larisch, Sarit and Rapp, Ulf R. and Rajalingam, Krishnaraj}
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<dcterms:abstract xml:lang="eng">Inhibitor of apoptosis (IAPs) proteins are characterized by the presence of evolutionarily conserved baculoviral inhibitor of apoptosis repeat (BIR) domains, predominantly known for their role in inhibiting caspases and, thereby, apoptosis. We have shown previously that multi-BIR domain-containing IAPs, cellular IAPs, and X-linked IAP can control tumor cell migration by directly regulating the protein stability of C-RAF kinase. Here, we extend our observations to a single BIR domain containing IAP family member melanoma-IAP (ML-IAP). We show that ML-IAP can directly bind to C-RAF and that ML-IAP depletion leads to an increase in C-RAF protein levels, MAPK activation, and cell migration in melanoma cells. Thus, our results unveil a thus far unknown role for ML-IAP in controlling C-RAF stability and cell migration.</dcterms:abstract>
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