Evaluation of the genotoxic potential of acrylamide : Arguments for the derivation of a tolerable daily intake (TDI value)

Guth, Sabine; Baum, Matthias; Cartus, Alexander T.; Diel, Patrick; Engel, Karl-Heinz; Engeli, Barbara; Epe, Bernd; Grune, Tilman; Leist, Marcel; Eisenbrand, Gerhard

Evaluation of the genotoxic potential of acrylamide : Arguments for the derivation of a tolerable daily intake (TDI value)

Dateien

Guth_2-12fyrji302qc40.PDFGröße: 1.83 MBDownloads: 81

Datum

2023

Autor:innen

Guth, Sabine

Baum, Matthias

Cartus, Alexander T.

Diel, Patrick

Engel, Karl-Heinz

Engeli, Barbara

Epe, Bernd

Grune, Tilman

Leist, Marcel

Eisenbrand, Gerhard

et al.

Open Access-Veröffentlichung

Open Access Hybrid

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Food and Chemical Toxicology. Elsevier. 2023, 173, 113632. ISSN 0278-6915. eISSN 1873-6351. Available under: doi: 10.1016/j.fct.2023.113632

Zusammenfassung

This opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) presents arguments for an updated risk assessment of diet-related exposure to acrylamide (AA), based on a critical review of scientific evidence relevant to low dose exposure. The SKLM arrives at the conclusion that as long as an appropriate exposure limit for AA is not exceeded, genotoxic effects resulting in carcinogenicity are unlikely to occur. Based on the totality of the evidence, the SKLM considers it scientifically justified to derive a tolerable daily intake (TDI) as a health-based guidance value.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Acrylamide, Non-linear dose response, Genotoxic carcinogen, Thresholded MoA, Risk assessment, Tolerable daily intake

Zitieren

ISO 690

GUTH, Sabine, Matthias BAUM, Alexander T. CARTUS, Patrick DIEL, Karl-Heinz ENGEL, Barbara ENGELI, Bernd EPE, Tilman GRUNE, Marcel LEIST, Gerhard EISENBRAND, 2023. Evaluation of the genotoxic potential of acrylamide : Arguments for the derivation of a tolerable daily intake (TDI value). In: Food and Chemical Toxicology. Elsevier. 2023, 173, 113632. ISSN 0278-6915. eISSN 1873-6351. Available under: doi: 10.1016/j.fct.2023.113632

BibTex

@article{Guth2023-01Evalu-59991,
  year={2023},
  doi={10.1016/j.fct.2023.113632},
  title={Evaluation of the genotoxic potential of acrylamide : Arguments for the derivation of a tolerable daily intake (TDI value)},
  volume={173},
  issn={0278-6915},
  journal={Food and Chemical Toxicology},
  author={Guth, Sabine and Baum, Matthias and Cartus, Alexander T. and Diel, Patrick and Engel, Karl-Heinz and Engeli, Barbara and Epe, Bernd and Grune, Tilman and Leist, Marcel and Eisenbrand, Gerhard},
  note={DFG: HE 2509/15-11 Article Number: 113632}
}

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Kommentar zur Publikation

DFG: HE 2509/15-11

Universitätsbibliographie

Ja

Begutachtet

Ja