Publikation:

Site-specific PEGylation of proteins containing unnatural amino acids

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2004

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Deiters, Alexander
Cropp, T. Ashton
Mukherji, Mridul
Schultz, Peter G.

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Bioorganic & Medicinal Chemistry Letters. 2004, 14(23), pp. 5743-5745. ISSN 0960-894X. Available under: doi: 10.1016/j.bmcl.2004.09.059

Zusammenfassung

Here, we report a generally applicable PEGylation methodology based on the site-specific incorporation of para-azidophenylalanine into proteins in yeast. The azido group was used in a mild [3+2] cycloaddition reaction with an alkyne derivatized PEG reagent to afford selectively PEGylated protein. This strategy should be useful for the generation of selectively PEGylated proteins for therapeutic applications.

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540 Chemie

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ISO 690DEITERS, Alexander, T. Ashton CROPP, Daniel SUMMERER, Mridul MUKHERJI, Peter G. SCHULTZ, 2004. Site-specific PEGylation of proteins containing unnatural amino acids. In: Bioorganic & Medicinal Chemistry Letters. 2004, 14(23), pp. 5743-5745. ISSN 0960-894X. Available under: doi: 10.1016/j.bmcl.2004.09.059
BibTex
@article{Deiters2004-12-06Sites-419,
  year={2004},
  doi={10.1016/j.bmcl.2004.09.059},
  title={Site-specific PEGylation of proteins containing unnatural amino acids},
  number={23},
  volume={14},
  issn={0960-894X},
  journal={Bioorganic & Medicinal Chemistry Letters},
  pages={5743--5745},
  author={Deiters, Alexander and Cropp, T. Ashton and Summerer, Daniel and Mukherji, Mridul and Schultz, Peter G.}
}
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