Publikation:

Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides

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Marx_0-329611.pdf
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1999

Autor:innen

Spichty, Martin
Amacker, Mario
Schwitter, Urs
Hübscher, Ulrich
Bickle, Thomas A.
Maga, Giovanni
Giese, Bernd

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Chemistry & Biology. 1999, 6(2), pp. 111-116. ISSN 1074-5521. eISSN 1879-1301. Available under: doi: 10.1016/S1074-5521(99)80007-6

Zusammenfassung

To gain a molecular understanding of a biochemical process, the crystal structure of enzymes that catalyze the reactions involved is extremely helpful. Often the question arises whether conformations obtained in this way appropriately reflect the reactivity of enzymes, however. Rates that characterize transitions are therefore compulsory experiments for the elucidation of the reaction mechanism. Such experiments have been performed for the reverse transcriptase of the type 1 human immunodeficiency virus (HIV-1 RT).

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540 Chemie

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ISO 690MARX, Andreas, Martin SPICHTY, Mario AMACKER, Urs SCHWITTER, Ulrich HÜBSCHER, Thomas A. BICKLE, Giovanni MAGA, Bernd GIESE, 1999. Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides. In: Chemistry & Biology. 1999, 6(2), pp. 111-116. ISSN 1074-5521. eISSN 1879-1301. Available under: doi: 10.1016/S1074-5521(99)80007-6
BibTex
@article{Marx1999-02Probi-33857,
  year={1999},
  doi={10.1016/S1074-5521(99)80007-6},
  title={Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides},
  number={2},
  volume={6},
  issn={1074-5521},
  journal={Chemistry & Biology},
  pages={111--116},
  author={Marx, Andreas and Spichty, Martin and Amacker, Mario and Schwitter, Urs and Hübscher, Ulrich and Bickle, Thomas A. and Maga, Giovanni and Giese, Bernd}
}
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