Publikation:

The Ubiquitin Ligase HectH9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation

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Datum

2005

Autor:innen

Adhikary, Sovana
Marinoni, Federica
Hock, Andreas
Hulleman, Esther
Popov, Nikita
Beier, Rudi
Bernard, Sandra
Quarto, Micaela
Capra, Maria
Goettig, Stephan
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http://nbn-resolving.de/urn:nbn:de:bsz:352-167715
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https://doi.org/10.1016/j.cell.2005.08.016
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Biologie: Publikationen
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Published

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Cell. 2005, 123(3), pp. 409-421. ISSN 0092-8674. Available under: doi: 10.1016/j.cell.2005.08.016

Zusammenfassung

The Myc oncoprotein forms a binary activating complex with its partner protein, Max, and a ternary repressive complex that, in addition to Max, contains the zinc finger protein Miz1. Here we show that the E3 ubiquitin ligase HectH9 ubiquitinates Myc in vivo and in vitro, forming a lysine 63-linked polyubiquitin chain. Miz1 inhibits this ubiquitination. HectH9-mediated ubiquitination of Myc is required for transactivation of multiple target genes, recruitment of the coactivator p300, and induction of cell proliferation by Myc. HectH9 is overexpressed in multiple human tumors and is essential for proliferation of a subset of tumor cells. Our results suggest that site-specific ubiquitination regulates the switch between an activating and a repressive state of the Myc protein, and they suggest a strategy to interfere with Myc function in vivo.

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570 Biowissenschaften, Biologie

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ISO 690ADHIKARY, Sovana, Federica MARINONI, Andreas HOCK, Esther HULLEMAN, Nikita POPOV, Rudi BEIER, Sandra BERNARD, Micaela QUARTO, Maria CAPRA, Stephan GOETTIG, Ulrike KOGEL, Martin SCHEFFNER, Kristian HELIN, Martin EILERS, 2005. The Ubiquitin Ligase HectH9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation. In: Cell. 2005, 123(3), pp. 409-421. ISSN 0092-8674. Available under: doi: 10.1016/j.cell.2005.08.016
BibTex
@article{Adhikary2005-11-04Ubiqu-16771,
  year={2005},
  doi={10.1016/j.cell.2005.08.016},
  title={The Ubiquitin Ligase HectH9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation},
  number={3},
  volume={123},
  issn={0092-8674},
  journal={Cell},
  pages={409--421},
  author={Adhikary, Sovana and Marinoni, Federica and Hock, Andreas and Hulleman, Esther and Popov, Nikita and Beier, Rudi and Bernard, Sandra and Quarto, Micaela and Capra, Maria and Goettig, Stephan and Kogel, Ulrike and Scheffner, Martin and Helin, Kristian and Eilers, Martin}
}
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