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Negative regulation of alkylation-induced sister-chromatid exchange by poly(ADP-ribose) polymerase-1 activity

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2000

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Meyer, Ralph
Müller, Marcus
Küpper, Jan-Heiner

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International Journal of Cancer. Wiley. 2000, 88(3), pp. 351-355. ISSN 0020-7136. eISSN 1097-0215. Available under: doi: 10.1002/1097-0215(20001101)88:3<351::AID-IJC5>3.0.CO;2-H

Zusammenfassung

One of the earliest responses to DNA damage in eukaryotic cells is activation of poly(ADP‐ribose) polymerase‐1 (PARP‐1), a DNA strand break–dependent nuclear enzyme which covalently modifies proteins with poly(ADP‐ribose). Here, we show that conditional over‐expression of PARP‐1 in stably transfected hamster cells, which causes cellular over‐accumulation of poly(ADP‐ribose) by several‐fold, strongly suppresses alkylation‐induced sister‐chromatid exchange (SCE), while cytotoxicity of alkylation treatment is slightly enhanced. Viewed together with the known potentiation of SCE by abrogation of PARP‐1 activity, our results provide evidence that PARP‐1 activity is an important regulator of alkylation‐induced SCE formation, imposing a control that is strictly negative and commensurate with the level of enzyme activity.

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570 Biowissenschaften, Biologie

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ISO 690MEYER, Ralph, Marcus MÜLLER, Sascha BENEKE, Jan-Heiner KÜPPER, Alexander BÜRKLE, 2000. Negative regulation of alkylation-induced sister-chromatid exchange by poly(ADP-ribose) polymerase-1 activity. In: International Journal of Cancer. Wiley. 2000, 88(3), pp. 351-355. ISSN 0020-7136. eISSN 1097-0215. Available under: doi: 10.1002/1097-0215(20001101)88:3<351::AID-IJC5>3.0.CO;2-H
BibTex
@article{Meyer2000Negat-52115,
  year={2000},
  doi={10.1002/1097-0215(20001101)88:3<351::AID-IJC5>3.0.CO;2-H},
  title={Negative regulation of alkylation-induced sister-chromatid exchange by poly(ADP-ribose) polymerase-1 activity},
  number={3},
  volume={88},
  issn={0020-7136},
  journal={International Journal of Cancer},
  pages={351--355},
  author={Meyer, Ralph and Müller, Marcus and Beneke, Sascha and Küpper, Jan-Heiner and Bürkle, Alexander}
}
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