Publikation: Alterations in cancer cell metabolism : The Warburg effect and metabolic adaptation
Lade...
Dateien
Datum
2015
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
oops
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Hybrid
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Genomics. 2015, 105(5-6), S. 275-281. ISSN 0888-7543. eISSN 1089-8646. Verfügbar unter: doi: 10.1016/j.ygeno.2015.03.001
Zusammenfassung
The Warburg effect means higher glucose uptake of cancer cells compared to normal tissues, whereas a smaller fraction of this glucose is employed for oxidative phosphorylation. With the advent of high throughput technologies and computational systems biology, cancer cell metabolism has been reinvestigated over the last decades toward identifying various events underlying "how" and "why" a cancer cell employs aerobic glycolysis. Significant progress has been shaped to revise the Warburg effect. In this study, we have integrated the gene expression of 13 different cancer cells with the genome-scale metabolic network of human (Recon1) based on the E-Flux method, and analyzed them based on constraint-based modeling. Results show that regardless of significant up- and down-regulated metabolic genes, the distribution of metabolic changes is similar in different cancer types. These findings support the theory that the Warburg effect is a consequence of metabolic adaptation in cancer cells.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
004 Informatik
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690
ASGARI, Yazdan, Zahra ZABIHINPOUR, Ali SALEHZADEH-YAZDI, Falk SCHREIBER, Ali MASOUDI-NEJAD, 2015. Alterations in cancer cell metabolism : The Warburg effect and metabolic adaptation. In: Genomics. 2015, 105(5-6), S. 275-281. ISSN 0888-7543. eISSN 1089-8646. Verfügbar unter: doi: 10.1016/j.ygeno.2015.03.001BibTex
@article{Asgari2015-05Alter-37710,
year={2015},
doi={10.1016/j.ygeno.2015.03.001},
title={Alterations in cancer cell metabolism : The Warburg effect and metabolic adaptation},
number={5-6},
volume={105},
issn={0888-7543},
journal={Genomics},
pages={275--281},
author={Asgari, Yazdan and Zabihinpour, Zahra and Salehzadeh-Yazdi, Ali and Schreiber, Falk and Masoudi-Nejad, Ali}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/37710">
<dc:creator>Masoudi-Nejad, Ali</dc:creator>
<dc:contributor>Schreiber, Falk</dc:contributor>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-02-24T14:11:07Z</dcterms:available>
<dcterms:issued>2015-05</dcterms:issued>
<dc:contributor>Salehzadeh-Yazdi, Ali</dc:contributor>
<dc:creator>Asgari, Yazdan</dc:creator>
<dc:creator>Zabihinpour, Zahra</dc:creator>
<dc:language>eng</dc:language>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36"/>
<dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/37710/1/Asgari_2-15hf5biwvp29j6.pdf"/>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<dc:creator>Schreiber, Falk</dc:creator>
<dc:contributor>Masoudi-Nejad, Ali</dc:contributor>
<dcterms:abstract xml:lang="eng">The Warburg effect means higher glucose uptake of cancer cells compared to normal tissues, whereas a smaller fraction of this glucose is employed for oxidative phosphorylation. With the advent of high throughput technologies and computational systems biology, cancer cell metabolism has been reinvestigated over the last decades toward identifying various events underlying "how" and "why" a cancer cell employs aerobic glycolysis. Significant progress has been shaped to revise the Warburg effect. In this study, we have integrated the gene expression of 13 different cancer cells with the genome-scale metabolic network of human (Recon1) based on the E-Flux method, and analyzed them based on constraint-based modeling. Results show that regardless of significant up- and down-regulated metabolic genes, the distribution of metabolic changes is similar in different cancer types. These findings support the theory that the Warburg effect is a consequence of metabolic adaptation in cancer cells.</dcterms:abstract>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-02-24T14:11:07Z</dc:date>
<dc:contributor>Asgari, Yazdan</dc:contributor>
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<dc:creator>Salehzadeh-Yazdi, Ali</dc:creator>
<dc:contributor>Zabihinpour, Zahra</dc:contributor>
<bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/37710"/>
<dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/37710/1/Asgari_2-15hf5biwvp29j6.pdf"/>
<dcterms:title>Alterations in cancer cell metabolism : The Warburg effect and metabolic adaptation</dcterms:title>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36"/>
</rdf:Description>
</rdf:RDF>Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
