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Immunogenetic losses co-occurred with seahorse male pregnancy and mutation in tlx1 accompanied functional asplenia

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2022

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Liu, Yali
Qu, Meng
Jiang, Han
Qin, Geng
Luo, Wei
Yu, Haiyan
Roth, Olivia
Lin, Qiang
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Nature Communications. Nature Publishing Group. 2022, 13(1), 7610. eISSN 2041-1723. Available under: doi: 10.1038/s41467-022-35338-7

Zusammenfassung

In the highly derived syngnathid fishes (pipefishes, seadragons & seahorses), the evolution of sex-role reversed brooding behavior culminated in the seahorse lineage's male pregnancy, whose males feature a specialized brood pouch into which females deposit eggs during mating. Then, eggs are intimately engulfed by a placenta-like tissue that facilitates gas and nutrient exchange. As fathers immunologically tolerate allogenic embryos, it was suggested that male pregnancy co-evolved with specific immunological adaptations. Indeed, here we show that a specific amino-acid replacement in the tlx1 transcription factor is associated with seahorses' asplenia (loss of spleen, an organ central in the immune system), as confirmed by a CRISPR-Cas9 experiment using zebrafish. Comparative genomics across the syngnathid phylogeny revealed that the complexity of the immune system gene repertoire decreases as parental care intensity increases. The synchronous evolution of immunogenetic alterations and male pregnancy supports the notion that male pregnancy co-evolved with the immunological tolerance of the embryo.

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570 Biowissenschaften, Biologie

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ISO 690LIU, Yali, Meng QU, Han JIANG, Ralf F. SCHNEIDER, Geng QIN, Wei LUO, Haiyan YU, Olivia ROTH, Axel MEYER, Qiang LIN, 2022. Immunogenetic losses co-occurred with seahorse male pregnancy and mutation in tlx1 accompanied functional asplenia. In: Nature Communications. Nature Publishing Group. 2022, 13(1), 7610. eISSN 2041-1723. Available under: doi: 10.1038/s41467-022-35338-7
BibTex
@article{Liu2022-12-09Immun-59504,
  year={2022},
  doi={10.1038/s41467-022-35338-7},
  title={Immunogenetic losses co-occurred with seahorse male pregnancy and mutation in tlx1 accompanied functional asplenia},
  number={1},
  volume={13},
  journal={Nature Communications},
  author={Liu, Yali and Qu, Meng and Jiang, Han and Schneider, Ralf F. and Qin, Geng and Luo, Wei and Yu, Haiyan and Roth, Olivia and Meyer, Axel and Lin, Qiang},
  note={Article Number: 7610}
}
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