Separation of Racemate from Excess Enantiomer of Chiral Nonracemic Compounds via Density Gradient Ultracentrifugation

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dc.contributor.authorMastai, Yitzhak
dc.contributor.authorVölkel, Antje
dc.contributor.authorCölfen, Helmut
dc.date.accessioned2017-09-20T08:54:01Z
dc.date.available2017-09-20T08:54:01Z
dc.date.issued2008-02eng
dc.description.abstractIn this study, it is shown that preparative density gradient ultracentrifugation can be applied to separate racemate crystals from excess enantiomer crystals. This was demonstrated for alanine crystals separated in a 50 wt % Nycodenz gradient. The recovery rates of the pure enantiomers from the mixtures were good (70−90%), and the separation method showed accuracy in the third digit of the density. As such density differences between racemate and enantiomers can be found for a wide range of crystalline chiral compounds, the presented separation method should be applicable to a large variety of substances on a preparative scale.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1021/ja067905ieng
dc.identifier.pmid18254622eng
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/40113
dc.language.isoengeng
dc.subject.ddc540eng
dc.titleSeparation of Racemate from Excess Enantiomer of Chiral Nonracemic Compounds via Density Gradient Ultracentrifugationeng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Mastai2008-02Separ-40113,
  year={2008},
  doi={10.1021/ja067905i},
  title={Separation of Racemate from Excess Enantiomer of Chiral Nonracemic Compounds via Density Gradient Ultracentrifugation},
  number={8},
  volume={130},
  issn={0002-7863},
  journal={Journal of the American Chemical Society : JACS},
  pages={2426--2427},
  author={Mastai, Yitzhak and Völkel, Antje and Cölfen, Helmut}
}
kops.citation.iso690MASTAI, Yitzhak, Antje VÖLKEL, Helmut CÖLFEN, 2008. Separation of Racemate from Excess Enantiomer of Chiral Nonracemic Compounds via Density Gradient Ultracentrifugation. In: Journal of the American Chemical Society : JACS. 2008, 130(8), pp. 2426-2427. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja067905ideu
kops.citation.iso690MASTAI, Yitzhak, Antje VÖLKEL, Helmut CÖLFEN, 2008. Separation of Racemate from Excess Enantiomer of Chiral Nonracemic Compounds via Density Gradient Ultracentrifugation. In: Journal of the American Chemical Society : JACS. 2008, 130(8), pp. 2426-2427. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja067905ieng
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kops.sourcefieldJournal of the American Chemical Society : JACS. 2008, <b>130</b>(8), pp. 2426-2427. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja067905ideu
kops.sourcefield.plainJournal of the American Chemical Society : JACS. 2008, 130(8), pp. 2426-2427. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja067905ideu
kops.sourcefield.plainJournal of the American Chemical Society : JACS. 2008, 130(8), pp. 2426-2427. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja067905ieng
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