Publikation:

C-(alpha-D-Glucopyranosyl)-phenyldiazomethanes - Irreversible Inhibitors of alpha-Glucosidase

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Geng_260610.pdf
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Datum

2013

Autor:innen

Faidallah, Hassan M.
Albar, Hassan A.
Mhkalid, Ibrahim A.

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http://nbn-resolving.de/urn:nbn:de:bsz:352-260610
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.bmc.2013.05.055
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Open Access-Veröffentlichung
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Chemie: Publikationen
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Published

Erschienen in

Bioorganic & Medicinal Chemistry. 2013, 21(16), pp. 4793-4802. ISSN 0968-0896. eISSN 1464-3391. Available under: doi: 10.1016/j.bmc.2013.05.055

Zusammenfassung

Several C-(alpha-D-glucopyranosyl)-phenyldiazomethanes, with different substituent groups at the paraposition of the phenyl ring, were prepared. The stabilities of these diazo compounds were investigated through NMR and UV monitoring. The para-cyano substituted diazo compound was found to be stable in neutral media (pH 7.0 buffer) and could be isolated. Inhibitory activity investigations indicated that this compound is an irreversible inhibitor against a-glucosidase from Saccharomyces cerevisiae.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
540 Chemie

Schlagwörter

a-Glucosidase, Irreversible inhibition, Diazo compounds, carbohydrate, synthesis

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ISO 690GENG, Yiqun, Amit KUMAR, Hassan M. FAIDALLAH, Hassan A. ALBAR, Ibrahim A. MHKALID, Richard R. SCHMIDT, 2013. C-(alpha-D-Glucopyranosyl)-phenyldiazomethanes - Irreversible Inhibitors of alpha-Glucosidase. In: Bioorganic & Medicinal Chemistry. 2013, 21(16), pp. 4793-4802. ISSN 0968-0896. eISSN 1464-3391. Available under: doi: 10.1016/j.bmc.2013.05.055
BibTex
@article{Geng2013-08-15Calph-26061,
  year={2013},
  doi={10.1016/j.bmc.2013.05.055},
  title={C-(alpha-D-Glucopyranosyl)-phenyldiazomethanes - Irreversible Inhibitors of alpha-Glucosidase},
  number={16},
  volume={21},
  issn={0968-0896},
  journal={Bioorganic & Medicinal Chemistry},
  pages={4793--4802},
  author={Geng, Yiqun and Kumar, Amit and Faidallah, Hassan M. and Albar, Hassan A. and Mhkalid, Ibrahim A. and Schmidt, Richard R.}
}
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