Publikation: Structure and Function of an RNA-Reading Thermostable DNA Polymerase
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2013
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Angewandte Chemie International Edition. 2013, 52(45), pp. 11935-11939. ISSN 1433-7851. eISSN 1521-3773. Available under: doi: 10.1002/anie.201306655
Zusammenfassung
Unfaithful: The structure of a DNA-dependent DNA polymerase, whose parental ancestor has no significant reverse transcriptase activity, was obtained for the first time incorporating a nucleotide against an RNA template and then structurally characterized. The DNA polymerase variant has significant reverse transcriptase activity that allows its application in PCR-based molecular diagnostics.
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Fachgebiet (DDC)
540 Chemie
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DNA polymerases, enzyme engineering, polymerase chain reaction, reverse transcription, structural biology
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BLATTER, Nina, Konrad BERGEN, Oliver NOLTE, Wolfram WELTE, Kay DIEDERICHS, Jutta MAYER, Markus WIELAND, Andreas MARX, 2013. Structure and Function of an RNA-Reading Thermostable DNA Polymerase. In: Angewandte Chemie International Edition. 2013, 52(45), pp. 11935-11939. ISSN 1433-7851. eISSN 1521-3773. Available under: doi: 10.1002/anie.201306655BibTex
@article{Blatter2013-11-04Struc-25125,
year={2013},
doi={10.1002/anie.201306655},
title={Structure and Function of an RNA-Reading Thermostable DNA Polymerase},
number={45},
volume={52},
issn={1433-7851},
journal={Angewandte Chemie International Edition},
pages={11935--11939},
author={Blatter, Nina and Bergen, Konrad and Nolte, Oliver and Welte, Wolfram and Diederichs, Kay and Mayer, Jutta and Wieland, Markus and Marx, Andreas}
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<dcterms:abstract xml:lang="eng">Unfaithful: The structure of a DNA-dependent DNA polymerase, whose parental ancestor has no significant reverse transcriptase activity, was obtained for the first time incorporating a nucleotide against an RNA template and then structurally characterized. The DNA polymerase variant has significant reverse transcriptase activity that allows its application in PCR-based molecular diagnostics.</dcterms:abstract>
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