Publikation: Role of Mechanotransduction and Tension in T Cell Function
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2018
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Frontiers in Immunology. 2018, 9, 2638. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2018.02638
Zusammenfassung
T cell migration from blood to, and within lymphoid organs and tissue, as well as, T cell activation rely on complex biochemical signaling events. But T cell migration and activation also take place in distinct mechanical environments and lead to drastic morphological changes and reorganization of the acto-myosin cytoskeleton. In this review we discuss how adhesion proteins and the T cell receptor act as mechanosensors to translate these mechanical contexts into signaling events. We further discuss how cell tension could bring a significant contribution to the regulation of T cell signaling and function.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
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Konferenz
Rezension
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ROSSY, Jérémie, Julia M. LAUFER, Daniel F. LEGLER, 2018. Role of Mechanotransduction and Tension in T Cell Function. In: Frontiers in Immunology. 2018, 9, 2638. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2018.02638BibTex
@article{Rossy2018-11-15Mecha-44056,
year={2018},
doi={10.3389/fimmu.2018.02638},
title={Role of Mechanotransduction and Tension in T Cell Function},
volume={9},
journal={Frontiers in Immunology},
author={Rossy, Jérémie and Laufer, Julia M. and Legler, Daniel F.},
note={Article Number: 2638}
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<dcterms:abstract xml:lang="eng">T cell migration from blood to, and within lymphoid organs and tissue, as well as, T cell activation rely on complex biochemical signaling events. But T cell migration and activation also take place in distinct mechanical environments and lead to drastic morphological changes and reorganization of the acto-myosin cytoskeleton. In this review we discuss how adhesion proteins and the T cell receptor act as mechanosensors to translate these mechanical contexts into signaling events. We further discuss how cell tension could bring a significant contribution to the regulation of T cell signaling and function.</dcterms:abstract>
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