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DNA Damage, DNA Repair, and Micronutrients in Aging

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2016

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https://doi.org/10.1016/B978-0-12-801816-3.00018-2
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MALAVOLTA, Marco, ed. and others. Molecular basis of nutrition and aging. Amsterdam: Academic Press, 2016, pp. 243-249. ISBN 978-0-12-801816-3. Available under: doi: 10.1016/B978-0-12-801816-3.00018-2

Zusammenfassung

The genome is continuously damaged due to both exogenous agents and endogenous processes. Exogenous agents are, for example, radiation or chemical compounds, whereas endogenous DNA damage mainly occurs due to reactive oxygen species (ROS) generated by cellular metabolic processes. In order to ensure DNA integrity cells have developed specialized DNA repair mechanisms. If DNA lesions are not detected or not resolved effectively DNA damage persists. Accumulation of DNA damage and the incapability of the cellular DNA repair machinery to fix DNA lesions seem to be contributors to aging and to age-associated diseases such as cancer. However, appropriated nutrition can protect against oxidative DNA damage and enhance DNA repair; therefore, dietary interventions might slow down aging processes and decrease cancer incidence.

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570 Biowissenschaften, Biologie

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Micronutrient, DNA damage, DNA repair, genomic stability

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ISO 690MORENO-VILLANUEVA, Maria, 2016. DNA Damage, DNA Repair, and Micronutrients in Aging. In: MALAVOLTA, Marco, ed. and others. Molecular basis of nutrition and aging. Amsterdam: Academic Press, 2016, pp. 243-249. ISBN 978-0-12-801816-3. Available under: doi: 10.1016/B978-0-12-801816-3.00018-2
BibTex
@incollection{MorenoVillanueva2016Damag-40504,
  year={2016},
  doi={10.1016/B978-0-12-801816-3.00018-2},
  title={DNA Damage, DNA Repair, and Micronutrients in Aging},
  isbn={978-0-12-801816-3},
  publisher={Academic Press},
  address={Amsterdam},
  booktitle={Molecular basis of nutrition and aging},
  pages={243--249},
  editor={Malavolta, Marco},
  author={Moreno-Villanueva, Maria}
}
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