Modulation of respiration pattern variability and its relation to anxiety symptoms in remitted recurrent depression

Kurzanzeige
dc.contributor.authorZamoscik, Vera
dc.contributor.authorSchmidt, Stephanie N. L.
dc.contributor.authorTimm, Christina
dc.contributor.authorKuehner, Christine
dc.contributor.authorKirsch, Peter
dc.date.accessioned2021-05-25T12:09:28Z
dc.date.available2021-05-25T12:09:28Z
dc.date.issued2020-07eng
dc.description.abstractBackground
Depression is related to default mode network (DMN) connectivity and higher respiration pattern variability (RPV). In addition, DMN connectivity and RPV are interrelated and predict a poorer clinical course of depression. The association of RPV and depression might further be boosted by anxiety levels. Aim of the present study was to investigate whether a mindfulness-based training in emotionally challenged remitted depressed participants (rMDD) leads to reduced DMN connectivity and lower RPV, and if RPV interacts with anxiety levels.

Methods
To challenge participants, sad mood was induced with keywords of personal negative life events in 49 rMDD during fMRI before and after a 4-week mindfulness-based attention training (MBAT) or progressive muscle relaxation. Respiration was measured by means of a built-in respiration belt.

Results
After both trainings, rMDD showed no significant changes in DMN connectivity. However, MBAT was effective in reducing the RPV which was related to lower anxiety levels especially in high anxious individuals.

Conclusions
RPV can be influenced by training which may hint to an underlying biological pathway of training effects. Importantly, these effects seem to be associated with anxiety levels. Therefore, respiration focused training might be an important tool assisting the treatment of depression and anxiety.		eng
dc.description.versionpublishedeng
dc.identifier.doi10.1016/j.heliyon.2020.e04261eng
dc.identifier.pmid32685708eng
dc.identifier.ppn175846822X
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/53742
dc.language.isoengeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPsychology, Neuroscience, Respiration, Variability, Depression, Anxiety, Intervention effect, DMNeng
dc.subject.ddc150eng
dc.titleModulation of respiration pattern variability and its relation to anxiety symptoms in remitted recurrent depressioneng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Zamoscik2020-07Modul-53742,
  year={2020},
  doi={10.1016/j.heliyon.2020.e04261},
  title={Modulation of respiration pattern variability and its relation to anxiety symptoms in remitted recurrent depression},
  number={7},
  volume={6},
  journal={Heliyon},
  author={Zamoscik, Vera and Schmidt, Stephanie N. L. and Timm, Christina and Kuehner, Christine and Kirsch, Peter},
  note={Article Number: e04261}
}
kops.citation.iso690ZAMOSCIK, Vera, Stephanie N. L. SCHMIDT, Christina TIMM, Christine KUEHNER, Peter KIRSCH, 2020. Modulation of respiration pattern variability and its relation to anxiety symptoms in remitted recurrent depression. In: Heliyon. Elsevier. 2020, 6(7), e04261. eISSN 2405-8440. Available under: doi: 10.1016/j.heliyon.2020.e04261deu
kops.citation.iso690ZAMOSCIK, Vera, Stephanie N. L. SCHMIDT, Christina TIMM, Christine KUEHNER, Peter KIRSCH, 2020. Modulation of respiration pattern variability and its relation to anxiety symptoms in remitted recurrent depression. In: Heliyon. Elsevier. 2020, 6(7), e04261. eISSN 2405-8440. Available under: doi: 10.1016/j.heliyon.2020.e04261eng
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    <dcterms:abstract xml:lang="eng">Background&lt;br /&gt;Depression is related to default mode network (DMN) connectivity and higher respiration pattern variability (RPV). In addition, DMN connectivity and RPV are interrelated and predict a poorer clinical course of depression. The association of RPV and depression might further be boosted by anxiety levels. Aim of the present study was to investigate whether a mindfulness-based training in emotionally challenged remitted depressed participants (rMDD) leads to reduced DMN connectivity and lower RPV, and if RPV interacts with anxiety levels.&lt;br /&gt;&lt;br /&gt;Methods&lt;br /&gt;To challenge participants, sad mood was induced with keywords of personal negative life events in 49 rMDD during fMRI before and after a 4-week mindfulness-based attention training (MBAT) or progressive muscle relaxation. Respiration was measured by means of a built-in respiration belt.&lt;br /&gt;&lt;br /&gt;Results&lt;br /&gt;After both trainings, rMDD showed no significant changes in DMN connectivity. However, MBAT was effective in reducing the RPV which was related to lower anxiety levels especially in high anxious individuals.&lt;br /&gt;&lt;br /&gt;Conclusions&lt;br /&gt;RPV can be influenced by training which may hint to an underlying biological pathway of training effects. Importantly, these effects seem to be associated with anxiety levels. Therefore, respiration focused training might be an important tool assisting the treatment of depression and anxiety.</dcterms:abstract>
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kops.sourcefield.plainHeliyon. Elsevier. 2020, 6(7), e04261. eISSN 2405-8440. Available under: doi: 10.1016/j.heliyon.2020.e04261eng
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