Publikation:

Spiny and soft-rayed fin domains in acanthomorph fish are established through a BMP-gremlin-shh signaling network

Lade...
Vorschaubild

Dateien

Hoech_2-19gdiyzlasi0n4.pdf
Hoech_2-19gdiyzlasi0n4.pdfGröße: 1.86 MBDownloads: 113

Datum

2021

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

European Union (EU): 293700

Projekt

Comparative genomics of parallel in repeated adaptive radiations (GenAdap)
Open Access-Veröffentlichung
Open Access Green
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences. 2021, 118(29), e2101783118. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.2101783118

Zusammenfassung

With over 18,000 species, the Acanthomorpha, or spiny-rayed fishes, form the largest and arguably most diverse radiation of vertebrates. One of the key novelties that contributed to their evolutionary success are the spiny rays in their fins that serve as a defense mechanism. We investigated the patterning mechanisms underlying the differentiation of median fin Anlagen into discrete spiny and soft-rayed domains during the ontogeny of the direct-developing cichlid fish Astatotilapia burtoni Distinct transcription factor signatures characterize these two fin domains, whereby mutually exclusive expression of hoxa13a/b with alx4a/b and tbx2b marks the spine to soft-ray boundary. The soft-ray domain is established by BMP inhibition via gremlin1b, which synergizes in the posterior fin with shh secreted from a zone of polarizing activity. Modulation of BMP signaling by chemical inhibition or gremlin1b CRISPR/Cas9 knockout induces homeotic transformations of spines into soft rays and vice versa. The expression of spine and soft-ray genes in nonacanthomorph fins indicates that a combination of exaptation and posterior expansion of an ancestral developmental program for the anterior fin margin allowed the evolution of robustly individuated spiny and soft-rayed domains. We propose that a repeated exaptation of such pattern might underly the convergent evolution of anterior spiny-fin elements across fishes.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

fin spine, acanthomorph, evolutionary key innovation, evo-devo, exaptation

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690HÖCH, Rebekka, Ralf F. SCHNEIDER, Alison KICKUTH, Axel MEYER, Joost M. WOLTERING, 2021. Spiny and soft-rayed fin domains in acanthomorph fish are established through a BMP-gremlin-shh signaling network. In: Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences. 2021, 118(29), e2101783118. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.2101783118
BibTex
@article{Hoch2021-07-20Spiny-54245,
  year={2021},
  doi={10.1073/pnas.2101783118},
  title={Spiny and soft-rayed fin domains in acanthomorph fish are established through a BMP-gremlin-shh signaling network},
  number={29},
  volume={118},
  issn={0027-8424},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  author={Höch, Rebekka and Schneider, Ralf F. and Kickuth, Alison and Meyer, Axel and Woltering, Joost M.},
  note={Article Number: e2101783118}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/54245">
    <dc:contributor>Kickuth, Alison</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-07-08T12:19:50Z</dcterms:available>
    <dc:creator>Schneider, Ralf F.</dc:creator>
    <dcterms:issued>2021-07-20</dcterms:issued>
    <dc:creator>Woltering, Joost M.</dc:creator>
    <dc:contributor>Meyer, Axel</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Kickuth, Alison</dc:creator>
    <dcterms:abstract xml:lang="eng">With over 18,000 species, the Acanthomorpha, or spiny-rayed fishes, form the largest and arguably most diverse radiation of vertebrates. One of the key novelties that contributed to their evolutionary success are the spiny rays in their fins that serve as a defense mechanism. We investigated the patterning mechanisms underlying the differentiation of median fin Anlagen into discrete spiny and soft-rayed domains during the ontogeny of the direct-developing cichlid fish Astatotilapia burtoni Distinct transcription factor signatures characterize these two fin domains, whereby mutually exclusive expression of hoxa13a/b with alx4a/b and tbx2b marks the spine to soft-ray boundary. The soft-ray domain is established by BMP inhibition via gremlin1b, which synergizes in the posterior fin with shh secreted from a zone of polarizing activity. Modulation of BMP signaling by chemical inhibition or gremlin1b CRISPR/Cas9 knockout induces homeotic transformations of spines into soft rays and vice versa. The expression of spine and soft-ray genes in nonacanthomorph fins indicates that a combination of exaptation and posterior expansion of an ancestral developmental program for the anterior fin margin allowed the evolution of robustly individuated spiny and soft-rayed domains. We propose that a repeated exaptation of such pattern might underly the convergent evolution of anterior spiny-fin elements across fishes.</dcterms:abstract>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/54245/1/Hoech_2-19gdiyzlasi0n4.pdf"/>
    <dc:contributor>Schneider, Ralf F.</dc:contributor>
    <dc:creator>Meyer, Axel</dc:creator>
    <dc:language>eng</dc:language>
    <dcterms:title>Spiny and soft-rayed fin domains in acanthomorph fish are established through a BMP-gremlin-shh signaling network</dcterms:title>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/54245/1/Hoech_2-19gdiyzlasi0n4.pdf"/>
    <dc:contributor>Woltering, Joost M.</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Höch, Rebekka</dc:creator>
    <dc:contributor>Höch, Rebekka</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-07-08T12:19:50Z</dc:date>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/54245"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen