Publikation:

Hemichannel composition and electrical synaptic transmission : molecular diversity and its implications for electrical rectification

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Palacios-Prado_0-257635.pdf
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Datum

2014

Autor:innen

Palacios-Prado, Nicolàs
Pereda, Albert E.

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-0-257635
DOI (zitierfähiger Link)
https://doi.org/10.3389/fncel.2014.00324
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CC BY 4.0

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Open Access-Veröffentlichung
Open Access Gold

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Biologie: Publikationen
Zukunftskolleg: Publikationen
Core Facility der Universität Konstanz

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Published

Erschienen in

Frontiers in Cellular Neuroscience. 2014, 8, 324. ISSN 1662-5102. Available under: doi: 10.3389/fncel.2014.00324

Zusammenfassung

Unapposed hemichannels (HCs) formed by hexamers of gap junction proteins are now known to be involved in various cellular processes under both physiological and pathological conditions. On the other hand, less is known regarding how differences in the molecular composition of HCs impact electrical synaptic transmission between neurons when they form intercellular heterotypic gap junctions (GJs). Here we review data indicating that molecular differences between apposed HCs at electrical synapses are generally associated with rectification of electrical transmission. Furthermore, this association has been observed at both innexin and connexin (Cx) based electrical synapses. We discuss the possible molecular mechanisms underlying electrical rectification, as well as the potential contribution of intracellular soluble factors to this phenomenon. We conclude that asymmetries in molecular composition and sensitivity to cellular factors of each contributing hemichannel can profoundly influence the transmission of electrical signals, endowing electrical synapses with more complex functional properties.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

gap junction, connexin, innexin, electrical synapse, asymmetry, rectification

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ISO 690PALACIOS-PRADO, Nicolàs, Wolf HUETTEROTH, Albert E. PEREDA, 2014. Hemichannel composition and electrical synaptic transmission : molecular diversity and its implications for electrical rectification. In: Frontiers in Cellular Neuroscience. 2014, 8, 324. ISSN 1662-5102. Available under: doi: 10.3389/fncel.2014.00324
BibTex
@article{PalaciosPrado2014Hemic-29141,
  year={2014},
  doi={10.3389/fncel.2014.00324},
  title={Hemichannel composition and electrical synaptic transmission : molecular diversity and its implications for electrical rectification},
  volume={8},
  issn={1662-5102},
  journal={Frontiers in Cellular Neuroscience},
  author={Palacios-Prado, Nicolàs and Huetteroth, Wolf and Pereda, Albert E.},
  note={Article Number: 324}
}
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