Publikation:

Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein

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2000

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Butz, Karin
Denk, Claudia
Ullmann, Angela
Hoppe-Seyler, Felix

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Proceedings of the National Academy of Sciences of the United States of America : PNAS. 2000, 97(12), pp. 6693-6697. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.110538897

Zusammenfassung

Certain types of human papillomaviruses (HPVs) are closely linked to the development of human cancers. Herein, it is shown that intracellular targeting of the HPV16 E6 oncoprotein by E6-binding peptide aptamers resulted in the apoptotic elimination of HPV16-positive cancer cells, whereas HPV-negative cells were not affected. These results provide direct experimental evidence that the HPV E6 oncoprotein has antiapoptotic activity in HPV-positive tumor cells that is required for their survival. The E6-targeting molecules identified herein have implications for the development of therapeutic strategies for the treatment of HPV-associated dysplasias and cancers.

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570 Biowissenschaften, Biologie

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ISO 690BUTZ, Karin, Claudia DENK, Angela ULLMANN, Martin SCHEFFNER, Felix HOPPE-SEYLER, 2000. Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein. In: Proceedings of the National Academy of Sciences of the United States of America : PNAS. 2000, 97(12), pp. 6693-6697. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.110538897
BibTex
@article{Butz2000-06-06Induc-42400,
  year={2000},
  doi={10.1073/pnas.110538897},
  title={Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein},
  number={12},
  volume={97},
  issn={0027-8424},
  journal={Proceedings of the National Academy of Sciences of the United States of America : PNAS},
  pages={6693--6697},
  author={Butz, Karin and Denk, Claudia and Ullmann, Angela and Scheffner, Martin and Hoppe-Seyler, Felix}
}
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