Publikation:

Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates

Vorschaubild

Dateien

Zhao_0-308422.pdf
Zhao_0-308422.pdfGröße: 834.39 KBDownloads: 287

Datum

2015

Autor:innen

Grützke, Martin

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-0-308422
DOI (zitierfähiger Link)
https://doi.org/10.1039/c5dt01618e
ArXiv-ID

Internationale Patentnummer

Link zur Lizenz
Attribution 3.0 Unported

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Hybrid

Sammlungen

Chemie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Dalton Transactions. 2015, 44(37), pp. 16475-16485. ISSN 1477-9226. eISSN 1477-9234. Available under: doi: 10.1039/c5dt01618e

Zusammenfassung

A series of novel sulfonamide substituted heteroleptic salan titanium(iv)-bis-chelates complexed to 2,6-pyridinedicarboxylic acid were synthesized, structurally characterized and evaluated for their anticancer activity against two human carcinoma cell lines. All cytotoxic complexes showed complete inhibition of cell growth at active concentration, two complexes based on pyrrolidine and azepane substituted sulfonamides displayed IC50 values below 1.7 μM and are more cytotoxic than cisplatin in both tested cell lines. The azepane substituted complex exhibited excellent activity with an IC50 value of 0.5 ± 0.1 μM in Hela S3 and 1.0 ± 0.1 μM in Hep G2.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
540 Chemie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690ZHAO, Tiankun, Martin GRÜTZKE, Kathrin H. GÖTZ, Tetiana DRUZHENKO, Thomas HUHN, 2015. Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates. In: Dalton Transactions. 2015, 44(37), pp. 16475-16485. ISSN 1477-9226. eISSN 1477-9234. Available under: doi: 10.1039/c5dt01618e
BibTex
@article{Zhao2015-09-15Synth-32224,
  year={2015},
  doi={10.1039/c5dt01618e},
  title={Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates},
  number={37},
  volume={44},
  issn={1477-9226},
  journal={Dalton Transactions},
  pages={16475--16485},
  author={Zhao, Tiankun and Grützke, Martin and Götz, Kathrin H. and Druzhenko, Tetiana and Huhn, Thomas}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/32224">
    <dc:creator>Huhn, Thomas</dc:creator>
    <dc:creator>Grützke, Martin</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-11-23T14:49:04Z</dcterms:available>
    <dc:contributor>Götz, Kathrin H.</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/32224/1/Zhao_0-308422.pdf"/>
    <dc:contributor>Zhao, Tiankun</dc:contributor>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/3.0/"/>
    <dcterms:issued>2015-09-15</dcterms:issued>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/32224"/>
    <dc:contributor>Huhn, Thomas</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:language>eng</dc:language>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:contributor>Grützke, Martin</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/32224/1/Zhao_0-308422.pdf"/>
    <dcterms:abstract xml:lang="eng">A series of novel sulfonamide substituted heteroleptic salan titanium(iv)-bis-chelates complexed to 2,6-pyridinedicarboxylic acid were synthesized, structurally characterized and evaluated for their anticancer activity against two human carcinoma cell lines. All cytotoxic complexes showed complete inhibition of cell growth at active concentration, two complexes based on pyrrolidine and azepane substituted sulfonamides displayed IC50 values below 1.7 μM and are more cytotoxic than cisplatin in both tested cell lines. The azepane substituted complex exhibited excellent activity with an IC50 value of 0.5 ± 0.1 μM in Hela S3 and 1.0 ± 0.1 μM in Hep G2.</dcterms:abstract>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-11-23T14:49:04Z</dc:date>
    <dc:rights>Attribution 3.0 Unported</dc:rights>
    <dcterms:title>Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates</dcterms:title>
    <dc:contributor>Druzhenko, Tetiana</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Druzhenko, Tetiana</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:creator>Götz, Kathrin H.</dc:creator>
    <dc:creator>Zhao, Tiankun</dc:creator>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen