Publikation: Growth cones of regenerating retinal axons contact a variety of cellular profiles in the transected goldfish optic nerve
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
Following optic nerve transection in goldfish, retinal axons regenerate. To determine what the growth cones use as a substrate for their growth, regenerating growth cones were labeled by horseradish peroxidase (HRP) application to the retina 5-6 days after intraorbital optic nerve section (ONS) and identified at 10-11 days after ONS in the brain sided (distal) portion of the optic nerve in thick and serial ultrathin sections. Leading growth cones (n = 5) were found in intimate contact with a variety of elements: with myelin fragments alone, with myelin fragments and glial cells, and with the basal lamina of the glia limitans and the surface of a fibroblast outside the boundary of previous fascicles.
In ultrathin sections of conventionally treated regenerating optic nerves, (unlabeled) axon profiles - in addition to myelin fragments - were seen to be in contact with an astrocyte and an oligodendrocyte, suggesting that the growth cones of these axons may have been associated with those cells. The data suggest that leading growth cones of regenerating axons may be capable of growing along myelin fragments and on a wide variety of cellular surfaces in the goldfish optic nerve.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
STROBEL, Gabrielle, Claudia STÜRMER, 1994. Growth cones of regenerating retinal axons contact a variety of cellular profiles in the transected goldfish optic nerve. In: Journal of Comparative Neurology. 1994, 346(3), pp. 435-448. ISSN 0021-9967. eISSN 1096-9861. Available under: doi: 10.1002/cne.903460307BibTex
@article{Strobel1994Growt-8666, year={1994}, doi={10.1002/cne.903460307}, title={Growth cones of regenerating retinal axons contact a variety of cellular profiles in the transected goldfish optic nerve}, number={3}, volume={346}, issn={0021-9967}, journal={Journal of Comparative Neurology}, pages={435--448}, author={Strobel, Gabrielle and Stürmer, Claudia} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/8666"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:45:32Z</dc:date> <dc:creator>Strobel, Gabrielle</dc:creator> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/> <dc:format>application/pdf</dc:format> <dc:creator>Stürmer, Claudia</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:issued>1994</dcterms:issued> <dc:contributor>Strobel, Gabrielle</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:45:32Z</dcterms:available> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:contributor>Stürmer, Claudia</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dcterms:title>Growth cones of regenerating retinal axons contact a variety of cellular profiles in the transected goldfish optic nerve</dcterms:title> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8666/1/Growth_cones_of_regenerating_retinal_axons_contact_a_variety_of_cellular_profiles_in_the_transected_goldfish_optic_nerve.pdf"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8666/1/Growth_cones_of_regenerating_retinal_axons_contact_a_variety_of_cellular_profiles_in_the_transected_goldfish_optic_nerve.pdf"/> <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights> <dcterms:bibliographicCitation>First publ. in: Journal of Comparative Neurology 346 (1994), pp. 435-448</dcterms:bibliographicCitation> <foaf:homepage rdf:resource="http://localhost:8080/"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8666"/> <dc:language>eng</dc:language> <dcterms:abstract xml:lang="eng">Following optic nerve transection in goldfish, retinal axons regenerate. To determine what the growth cones use as a substrate for their growth, regenerating growth cones were labeled by horseradish peroxidase (HRP) application to the retina 5-6 days after intraorbital optic nerve section (ONS) and identified at 10-11 days after ONS in the brain sided (distal) portion of the optic nerve in thick and serial ultrathin sections. Leading growth cones (n = 5) were found in intimate contact with a variety of elements: with myelin fragments alone, with myelin fragments and glial cells, and with the basal lamina of the glia limitans and the surface of a fibroblast outside the boundary of previous fascicles.<br />In ultrathin sections of conventionally treated regenerating optic nerves, (unlabeled) axon profiles - in addition to myelin fragments - were seen to be in contact with an astrocyte and an oligodendrocyte, suggesting that the growth cones of these axons may have been associated with those cells. The data suggest that leading growth cones of regenerating axons may be capable of growing along myelin fragments and on a wide variety of cellular surfaces in the goldfish optic nerve.</dcterms:abstract> </rdf:Description> </rdf:RDF>