Activating the ubiquitin family : UBA6 challenges the field

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2008
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Zusammenfassung

Since its discovery in 1981, ubiquitin-activating enzyme 1 was thought to be the only E1-type enzyme responsible for ubiquitin activation. Recently, a relatively uncharacterized E1 enzyme, designated ubiquitin-like modifier activating enzyme 6, was also shown to activate ubiquitin. Ubiquitin-activating enzyme 1 and ubiquitin-like modifier activating enzyme 6 are both essential proteins, and each uses a different spectrum of ubiquitin-conjugating (E2) enzymes. Ubiquitin-like modifier activating enzyme 6 activates not only ubiquitin, but also the ubiquitin-like modifier FAT10 (human leukocyte antigen F-associated transcript 10), which, similarly to ubiquitin, serves as a signal for proteasomal degradation. This new layer of regulation in ubiquitin activation markedly increases the versatility of the ubiquitin conjugation system.

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570 Biowissenschaften, Biologie
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ISO 690GRÖTTRUP, Marcus, Christiane PELZER, Gunter SCHMIDTKE, Kay HOFMANN, 2008. Activating the ubiquitin family : UBA6 challenges the field. In: Trends in Biochemical Sciences. 2008, 33(5), pp. 230-237. ISSN 0968-0004. Available under: doi: 10.1016/j.tibs.2008.01.005
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@article{Grottrup2008Activ-1219,
  year={2008},
  doi={10.1016/j.tibs.2008.01.005},
  title={Activating the ubiquitin family : UBA6 challenges the field},
  number={5},
  volume={33},
  issn={0968-0004},
  journal={Trends in Biochemical Sciences},
  pages={230--237},
  author={Gröttrup, Marcus and Pelzer, Christiane and Schmidtke, Gunter and Hofmann, Kay}
}
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