Publikation: An altered T cell repertoire in MECL-1-deficient mice
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The journal of immunology. 2006, 176(11), pp. 6665-6672. ISSN 0022-1767. eISSN 1550-6606. Available under: doi: 10.4049/jimmunol.176.11.6665
Zusammenfassung
Immunoproteasome subunits low-molecular mass polypeptide (LMP)2 and LMP7 affect Ag presentation by MHC class I molecules.
In the present study, we investigated the function of the third immunosubunit LMP10/multicatalytic endopeptidase complexlike (MECL)-1 ( 2i) in MECL-1 gene-targeted mice. The number of CD8 splenocytes in MECL-1 / mice was 20% lower than in wild-type mice. Infection with lymphocytic choriomeningitis virus (LCMV) elicited a markedly reduced cytotoxic T cell (CTL) response to the LCMV epitopes GP276–286/Db and NP205–212/Kb in MECL-1 / mice. The weak CTL response to GP276–286/Db was not due to an impaired generation of this epitope but was attributed to a decreased precursor frequency of GP276–286/Db-specific T cells. The expansion of TCR-V 10 T cells, which contain GP276–286/Db-specific cells, was reduced in LCMVinfected MECL-1 / mice. Taken together, our data reveal an in vivo function of MECL-1 in codetermining the T cell repertoire for an antiviral CTL response.
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BASLER, Michael, Jacqueline MOEBIUS, Laura ELENICH, Marcus GRÖTTRUP, John J. MONACO, 2006. An altered T cell repertoire in MECL-1-deficient mice. In: The journal of immunology. 2006, 176(11), pp. 6665-6672. ISSN 0022-1767. eISSN 1550-6606. Available under: doi: 10.4049/jimmunol.176.11.6665BibTex
@article{Basler2006alter-22112,
year={2006},
doi={10.4049/jimmunol.176.11.6665},
title={An altered T cell repertoire in MECL-1-deficient mice},
number={11},
volume={176},
issn={0022-1767},
journal={The journal of immunology},
pages={6665--6672},
author={Basler, Michael and Moebius, Jacqueline and Elenich, Laura and Gröttrup, Marcus and Monaco, John J.}
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<dcterms:abstract xml:lang="eng">Immunoproteasome subunits low-molecular mass polypeptide (LMP)2 and LMP7 affect Ag presentation by MHC class I molecules.<br />In the present study, we investigated the function of the third immunosubunit LMP10/multicatalytic endopeptidase complexlike (MECL)-1 ( 2i) in MECL-1 gene-targeted mice. The number of CD8 splenocytes in MECL-1 / mice was 20% lower than in wild-type mice. Infection with lymphocytic choriomeningitis virus (LCMV) elicited a markedly reduced cytotoxic T cell (CTL) response to the LCMV epitopes GP276–286/Db and NP205–212/Kb in MECL-1 / mice. The weak CTL response to GP276–286/Db was not due to an impaired generation of this epitope but was attributed to a decreased precursor frequency of GP276–286/Db-specific T cells. The expansion of TCR-V 10 T cells, which contain GP276–286/Db-specific cells, was reduced in LCMVinfected MECL-1 / mice. Taken together, our data reveal an in vivo function of MECL-1 in codetermining the T cell repertoire for an antiviral CTL response.</dcterms:abstract>
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