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Increased daytime and awakening salivary free aldosterone in essential hypertensive men

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2024

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von Känel, Roland
Zuccarella-Hackl, Claudia
Wiest, Roland

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oops

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Deutsche Forschungsgemeinschaft (DFG): EXC 2117–422037984

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Published

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Frontiers in Cardiovascular Medicine. Frontiers. 2024, 11, 1335329. eISSN 2297-055X. Verfügbar unter: doi: 10.3389/fcvm.2024.1335329

Zusammenfassung

Background: While aldosterone plays an important role in blood pressure regulation, its role in essential hypertension (EHT) remains unclear. Here, we systematically investigated the secretion of biologically-active free aldosterone in saliva in response to awakening (AldAR) and during the day (AldDay) in EHT compared to normotensive controls (NT).In 30 men with EHT and 30 age-matched NT, AldAR saliva samples were collected immediately after awakening and 15, 30, 45, and 60 min thereafter and AldDay samples were collected from 08:30-22:00 h on two consecutive days.Results: Over the course of the day, men with EHT had higher repeated AldDay levels compared to NT (p = .002) with higher concentrations in the morning hours (p's ≤ .047), a steeper decline over the course of the day (p's ≤ .018), and similar concentrations in the evening (p's ≥ .21). Regarding AldAR, we observed higher concentrations in EHT at awakening (p = .017) and borderline higher concentrations at 15 min (p = .086). No differences were found 30-60 min after awakening (p's ≥ .34). Analyses with repeated and aggregated AldAR levels resulted in borderline significantly higher free aldosterone in EHT (p's ≤ .077). Complementary analyses confirmed linear associations between higher blood pressure and higher AldAR and AldDay levels.Conclusions: Our data point to elevated salivary free aldosterone secretion in EHT over the course of the day, particularly in the morning hours. As the free aldosterone fraction is considered biologically active, our data may point to a biological mechanism underlying EHT.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
150 Psychologie

Schlagwörter

salivary free aldosterone, Awakening response, daytime levels, essential hypertension, Blood Pressure

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Rezension
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ISO 690GIDEON, Angelina, Roland VON KÄNEL, Cathy DEGROOTE, Livia THOMAS, Livia THOMAS, Claudia ZUCCARELLA-HACKL, Roland WIEST, Petra H. WIRTZ, 2024. Increased daytime and awakening salivary free aldosterone in essential hypertensive men. In: Frontiers in Cardiovascular Medicine. Frontiers. 2024, 11, 1335329. eISSN 2297-055X. Verfügbar unter: doi: 10.3389/fcvm.2024.1335329
BibTex
@article{Gideon2024-06-25Incre-70081,
  year={2024},
  doi={10.3389/fcvm.2024.1335329},
  title={Increased daytime and awakening salivary free aldosterone in essential hypertensive men},
  volume={11},
  journal={Frontiers in Cardiovascular Medicine},
  author={Gideon, Angelina and von Känel, Roland and Degroote, Cathy and Thomas, Livia and Thomas, Livia and Zuccarella-Hackl, Claudia and Wiest, Roland and Wirtz, Petra H.},
  note={Article Number: 1335329}
}
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