Publikation:

Response to Agomelatine Treatment is Independent of Smoking Status and Dosage : Results From the AGOPSYCH Study

Vorschaubild

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2019

Autor:innen

Englisch, Susanne
Jung, Hanna Sophie
Lewien, Antje
Nowak, Ulrike
Braun, Hanna
Eisenacher, Sarah
Thiem, Jascha
Meyer-Lindenberg, Andreas
Zink, Mathias

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
DOI (zitierfähiger Link)
https://doi.org/10.1055/a-0606-5240
ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung

Sammlungen

Psychologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Pharmacopsychiatry. Georg Thieme Verlag. 2019, 52(3), pp. 142-146. ISSN 0031-7098. eISSN 1439-0795. Available under: doi: 10.1055/a-0606-5240

Zusammenfassung

Introduction: Cigarette smoking influences response to antidepressant treatment. It accelerates the metabolism of several cytochrome P450 (CYP) subtypes, including CYP1A2, and therefore bears the risk of pharmacokinetic interactions with psychotropic drugs using that pathway. Agomelatine is a substrate of CYP1A2; the association between nicotine use and agomelatine dosage, however, has never been studied before.

Methods: Smoking habits were correlated with agomelatine doses and treatment outcomes in a sample of 27 patients with lifetime diagnoses within the schizophrenia spectrum who received agomelatine treatment in addition to their stable antipsychotic treatment regimen because of depressive symptoms.

Results: No interactions were found between smoking status and agomelatine dosage, and treatment outcomes did not differ between smokers and nonsmokers.

Discussion: Agomelatine efficacy appears to be independent of dosage and smoking status, pointing toward mechanisms beyond mere dose-response relationships. Further research will be necessary to validate these findings.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
150 Psychologie

Schlagwörter

agomelatine, nicotine, smoking, interaction, pharmacokinetics, CYP1A2, schizophrenia, depression

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690ENGLISCH, Susanne, Hanna Sophie JUNG, Antje LEWIEN, Anna BECKER, Ulrike NOWAK, Hanna BRAUN, Sarah EISENACHER, Jascha THIEM, Andreas MEYER-LINDENBERG, Mathias ZINK, 2019. Response to Agomelatine Treatment is Independent of Smoking Status and Dosage : Results From the AGOPSYCH Study. In: Pharmacopsychiatry. Georg Thieme Verlag. 2019, 52(3), pp. 142-146. ISSN 0031-7098. eISSN 1439-0795. Available under: doi: 10.1055/a-0606-5240
BibTex
@article{Englisch2019-03Respo-54114,
  year={2019},
  doi={10.1055/a-0606-5240},
  title={Response to Agomelatine Treatment is Independent of Smoking Status and Dosage : Results From the AGOPSYCH Study},
  number={3},
  volume={52},
  issn={0031-7098},
  journal={Pharmacopsychiatry},
  pages={142--146},
  author={Englisch, Susanne and Jung, Hanna Sophie and Lewien, Antje and Becker, Anna and Nowak, Ulrike and Braun, Hanna and Eisenacher, Sarah and Thiem, Jascha and Meyer-Lindenberg, Andreas and Zink, Mathias}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/54114">
    <dcterms:abstract xml:lang="eng">Introduction: Cigarette smoking influences response to antidepressant treatment. It accelerates the metabolism of several cytochrome P450 (CYP) subtypes, including CYP1A2, and therefore bears the risk of pharmacokinetic interactions with psychotropic drugs using that pathway. Agomelatine is a substrate of CYP1A2; the association between nicotine use and agomelatine dosage, however, has never been studied before.&lt;br /&gt;&lt;br /&gt;Methods: Smoking habits were correlated with agomelatine doses and treatment outcomes in a sample of 27 patients with lifetime diagnoses within the schizophrenia spectrum who received agomelatine treatment in addition to their stable antipsychotic treatment regimen because of depressive symptoms.&lt;br /&gt;&lt;br /&gt;Results: No interactions were found between smoking status and agomelatine dosage, and treatment outcomes did not differ between smokers and nonsmokers.&lt;br /&gt;&lt;br /&gt;Discussion:  Agomelatine efficacy appears to be independent of dosage and smoking status, pointing toward mechanisms beyond mere dose-response relationships. Further research will be necessary to validate these findings.</dcterms:abstract>
    <dcterms:title>Response to Agomelatine Treatment is Independent of Smoking Status and Dosage : Results From the AGOPSYCH Study</dcterms:title>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:language>eng</dc:language>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Meyer-Lindenberg, Andreas</dc:creator>
    <dc:contributor>Braun, Hanna</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <dc:creator>Nowak, Ulrike</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:contributor>Nowak, Ulrike</dc:contributor>
    <dc:contributor>Lewien, Antje</dc:contributor>
    <dc:creator>Braun, Hanna</dc:creator>
    <dc:contributor>Englisch, Susanne</dc:contributor>
    <dc:creator>Eisenacher, Sarah</dc:creator>
    <dc:contributor>Thiem, Jascha</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/54114"/>
    <dc:contributor>Becker, Anna</dc:contributor>
    <dc:creator>Thiem, Jascha</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Becker, Anna</dc:creator>
    <dc:creator>Lewien, Antje</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-06-28T08:42:32Z</dc:date>
    <dcterms:issued>2019-03</dcterms:issued>
    <dc:contributor>Meyer-Lindenberg, Andreas</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-06-28T08:42:32Z</dcterms:available>
    <dc:contributor>Jung, Hanna Sophie</dc:contributor>
    <dc:creator>Zink, Mathias</dc:creator>
    <dc:contributor>Eisenacher, Sarah</dc:contributor>
    <dc:creator>Englisch, Susanne</dc:creator>
    <dc:creator>Jung, Hanna Sophie</dc:creator>
    <dc:contributor>Zink, Mathias</dc:contributor>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen