Publikation:

Investigating the Human Host—ssRNA Virus Interaction Landscape Using the SMEAGOL Toolbox

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2022

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Lal, Avantika
Galvao Ferrarini, Mariana

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Published

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Viruses. MDPI. 2022, 14(7), 1436. eISSN 1999-4915. Available under: doi: 10.3390/v14071436

Zusammenfassung

Viruses have evolved numerous mechanisms to exploit the molecular machinery of their host cells, including the broad spectrum of host RNA-binding proteins (RBPs). However, the RBP interactomes of most viruses are largely unknown. To shed light on the interaction landscape of RNA viruses with human host cell RBPs, we have analysed 197 single-stranded RNA (ssRNA) viral genome sequences and found that the majority of ssRNA virus genomes are significantly enriched or depleted in motifs for specific human RBPs, suggesting selection pressure on these interactions. To facilitate tailored investigations and the analysis of genomes sequenced in future, we have released our methodology as a fast and user-friendly computational toolbox named SMEAGOL. Our resources will contribute to future studies of specific ssRNA virus—host cell interactions and support the identification of antiviral drug targets.

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

RNA virus genome; RNA-binding protein; virus-host interaction; toolbox

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ISO 690LAL, Avantika, Mariana GALVAO FERRARINI, Andreas J. GRUBER, 2022. Investigating the Human Host—ssRNA Virus Interaction Landscape Using the SMEAGOL Toolbox. In: Viruses. MDPI. 2022, 14(7), 1436. eISSN 1999-4915. Available under: doi: 10.3390/v14071436
BibTex
@article{Lal2022-07Inves-57989,
  year={2022},
  doi={10.3390/v14071436},
  title={Investigating the Human Host—ssRNA Virus Interaction Landscape Using the SMEAGOL Toolbox},
  number={7},
  volume={14},
  journal={Viruses},
  author={Lal, Avantika and Galvao Ferrarini, Mariana and Gruber, Andreas J.},
  note={Article Number: 1436}
}
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