Publikation:

Dendritic Cells Generated From Patients With Androgen-Independent Prostate Cancer Are Not Impaired in Migration and T-Cell Stimulation

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Waeckerle-Men_221197.pdf
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Datum

2005

Autor:innen

Waeckerle-Men, Ying
Moos, Roger von
Classon, Brendan J.
Scandella, Elke
Schmid, Hans-Peter
Ludewig, Burkhard
Gillessen, Silke

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http://nbn-resolving.de/urn:nbn:de:bsz:352-221197
DOI (zitierfähiger Link)
https://doi.org/10.1002/pros.20231
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Open Access Green

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Biologie: Publikationen
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Zeitschriftenartikel
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Published

Erschienen in

The Prostate. 2005, 64(4), pp. 323-331. ISSN 0270-4137. eISSN 1097-0045. Available under: doi: 10.1002/pros.20231

Zusammenfassung

BACKGROUND Dendritic cell (DC)-based vaccination has been investigated as immunotherapy for several types of cancer. A potential drawback to vaccination with autologous monocyte-derived DCs (MoDCs) could be that MoDCs from patients are functionally impaired. In case of androgen-independent prostate cancer (CaP), the cancer itself, diverse prior therapies, and the hormone manipulation may affect the immune system.

METHODS. MoDCs from patients suffering from androgen-independent CaP were generated according to a clinically applicable protocol to evaluate the phenotype, maturation capacity, migration, and T-cell stimulation of these cells compared with those generated from tumor-free donors.

RESULTS MoDCs generated from CaP patients could be fully matured and efficiently migrated towards the chemokine CCL21. They had a strong potency to activate allogeneicCD4þ and CD8þ T-cells and to present antigens to specific CTL.

CONCLUSIONS Our data suggest that MoDCs from patients with androgen-independent CaP are functionally intact and hence qualify as cellular vaccines for immunotherapy of advanced stage CaP.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

prostate cancer, cancer vaccine, monocyte-derived dendritic cells (MoDCs), DC phenotype and functions

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ISO 690WAECKERLE-MEN, Ying, Edith UETZ-VON ALLMEN, Roger von MOOS, Brendan J. CLASSON, Elke SCANDELLA, Hans-Peter SCHMID, Burkhard LUDEWIG, Marcus GRÖTTRUP, Silke GILLESSEN, 2005. Dendritic Cells Generated From Patients With Androgen-Independent Prostate Cancer Are Not Impaired in Migration and T-Cell Stimulation. In: The Prostate. 2005, 64(4), pp. 323-331. ISSN 0270-4137. eISSN 1097-0045. Available under: doi: 10.1002/pros.20231
BibTex
@article{WaeckerleMen2005-09-01Dendr-22119,
  year={2005},
  doi={10.1002/pros.20231},
  title={Dendritic Cells Generated From Patients With Androgen-Independent Prostate Cancer Are Not Impaired in Migration and T-Cell Stimulation},
  number={4},
  volume={64},
  issn={0270-4137},
  journal={The Prostate},
  pages={323--331},
  author={Waeckerle-Men, Ying and Uetz-von Allmen, Edith and Moos, Roger von and Classon, Brendan J. and Scandella, Elke and Schmid, Hans-Peter and Ludewig, Burkhard and Gröttrup, Marcus and Gillessen, Silke}
}
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