Publikation:

Induction of apoptosis in yeast by L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma

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2008

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Ande, Sudharsana Rao
Fussi, Heike
Knauer, Heide
Murkovic, Michael
Fröhlich, Kai-Uwe
Macheroux, Peter

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https://doi.org/10.1002/yea.1592
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Biologie: Publikationen
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Yeast. Wiley-Blackwell. 2008, 25(5), pp. 349-357. ISSN 0749-503X. eISSN 1097-0061. Available under: doi: 10.1002/yea.1592

Zusammenfassung

Here we report for the first time that L-amino acid oxidase (LAAO), a major component of snake venom, induces apoptosis in yeast. The causative agent for induction of apoptosis has been shown to be hydrogen peroxide, produced by the enzymatic activity of LAAO. However, the addition of catalase, a specific hydrogen peroxide scavenger, does not prevent cell demise completely. Intriguingly, depletion of leucine from the medium by LAAO and the interaction of LAAO with yeast cells are shown to be the major factors responsible for cell demise in the presence of catalase.

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570 Biowissenschaften, Biologie

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ISO 690ANDE, Sudharsana Rao, Heike FUSSI, Heide KNAUER, Michael MURKOVIC, Sandro GHISLA, Kai-Uwe FRÖHLICH, Peter MACHEROUX, 2008. Induction of apoptosis in yeast by L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma. In: Yeast. Wiley-Blackwell. 2008, 25(5), pp. 349-357. ISSN 0749-503X. eISSN 1097-0061. Available under: doi: 10.1002/yea.1592
BibTex
@article{Ande2008-05Induc-58672,
  year={2008},
  doi={10.1002/yea.1592},
  title={Induction of apoptosis in yeast by L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma},
  number={5},
  volume={25},
  issn={0749-503X},
  journal={Yeast},
  pages={349--357},
  author={Ande, Sudharsana Rao and Fussi, Heike and Knauer, Heide and Murkovic, Michael and Ghisla, Sandro and Fröhlich, Kai-Uwe and Macheroux, Peter}
}
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