Reggie/flotillin and the targeted delivery of cargo

Stürmer, Claudia

Reggie/flotillin and the targeted delivery of cargo

Files

Stuermer_Reggie1.pdf(3.64 MB)

Date

2011

Publication type

Journal article

Published in

Journal of Neurochemistry ; 116 (2011), 5. - pp. 708-713. - ISSN 0022-3042. - eISSN 1471-4159

Abstract

The two proteins reggie-1/flotillin-2 and reggie-2/flotillin-1 form microdomains at the plasma membrane and at intracellular compartments where src tyrosine kinases associate with them. Specific GPI-anchored proteins, in particular prion protein and Thy-1, co-cluster with reggie microdomains at the plasma membrane and elicit signal transduction in association with reggies which regulates the activation of several GTPases involved in the recruitment of specific membrane proteins from intracellular carriers to target sites of the cell membrane in a cell type-specific manner. For example, prion protein and reggie regulate the recruitment and targeted delivery of the T cell receptor complex to the T cell cap, of E-cadherin to cell-cell contact sites in epithelial cells, and of bulk membrane and growth receptors to the growth cone in developing neurons. Evidence is accumulating that reggies are involved in guiding the cell-type-specific membrane proteins from the intracellular compartments to their target sites at the cell membrane, a function required in all cells which explains why reggies are expressed in many or all cells in invertebrates and vertebrates.

Subject (DDC)

570 Biosciences, Biology

Keywords

Animals Antigens,Thy-1/physiology Axons/physiology Cadherins/metabolism Humans Membrane Microdomains/*metabolism Membrane Proteins/*metabolism Models,Biological Neurons/cytology Prions/physiology Signal Transduction/physiology src-Family Kinases/metabolism

Cite This

ISO 690

STÜRMER, Claudia, 2011. Reggie/flotillin and the targeted delivery of cargo. In: Journal of Neurochemistry. 116(5), pp. 708-713. ISSN 0022-3042. eISSN 1471-4159. Available under: doi: 10.1111/j.1471-4159.2010.07007.x

BibTex

@article{Sturmer2011-03Reggi-14599,
  year={2011},
  doi={10.1111/j.1471-4159.2010.07007.x},
  title={Reggie/flotillin and the targeted delivery of cargo},
  number={5},
  volume={116},
  issn={0022-3042},
  journal={Journal of Neurochemistry},
  pages={708--713},
  author={Stürmer, Claudia}
}

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Bibliography of Konstanz

Yes