Publikation: Comparative Ochratoxin Toxicity : A Review of the Available Data
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2015
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Bingle, Lewis E. H.
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Toxins. 2015, 7(10), pp. 4253-4282. eISSN 2072-6651. Available under: doi: 10.3390/toxins7104253
Zusammenfassung
Ochratoxins are a group of mycotoxins produced by a variety of moulds. Ochratoxin A (OTA), the most prominent member of this toxin family, was first described by van der Merwe et al. in Nature in 1965. Dietary exposure to OTA represents a serious health issue and has been associated with several human and animal diseases including poultry ochratoxicosis, porcine nephropathy, human endemic nephropathies and urinary tract tumours in humans. More than 30 years ago, OTA was shown to be carcinogenic in rodents and since then extensive research has been performed in order to investigate its mode of action, however, this is still under debate. OTA is regarded as the most toxic family member, however, other ochratoxins or their metabolites and, in particular, ochratoxin mixtures or combinations with other mycotoxins may represent serious threats to human and animal health. This review summarises and evaluates current knowledge about the differential and comparative toxicity of the ochratoxin group.
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570 Biowissenschaften, Biologie
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HEUSSNER, Alexandra H., Lewis E. H. BINGLE, 2015. Comparative Ochratoxin Toxicity : A Review of the Available Data. In: Toxins. 2015, 7(10), pp. 4253-4282. eISSN 2072-6651. Available under: doi: 10.3390/toxins7104253BibTex
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year={2015},
doi={10.3390/toxins7104253},
title={Comparative Ochratoxin Toxicity : A Review of the Available Data},
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volume={7},
journal={Toxins},
pages={4253--4282},
author={Heussner, Alexandra H. and Bingle, Lewis E. H.}
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<dcterms:abstract xml:lang="eng">Ochratoxins are a group of mycotoxins produced by a variety of moulds. Ochratoxin A (OTA), the most prominent member of this toxin family, was first described by van der Merwe et al. in Nature in 1965. Dietary exposure to OTA represents a serious health issue and has been associated with several human and animal diseases including poultry ochratoxicosis, porcine nephropathy, human endemic nephropathies and urinary tract tumours in humans. More than 30 years ago, OTA was shown to be carcinogenic in rodents and since then extensive research has been performed in order to investigate its mode of action, however, this is still under debate. OTA is regarded as the most toxic family member, however, other ochratoxins or their metabolites and, in particular, ochratoxin mixtures or combinations with other mycotoxins may represent serious threats to human and animal health. This review summarises and evaluates current knowledge about the differential and comparative toxicity of the ochratoxin group.</dcterms:abstract>
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