Publikation:

Increased erythropoietin production after myocardial infarction in mice

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Mengozzi_838.pdf
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Datum

2006

Autor:innen

Mengozzi, M.
Latini, Renato
Salio, M.
Sfacteria, Alessandra
Piedimonte, G.
Gammeltoft Gerwien, Jens
Sirén, Anna-Leena
Ghezzi, Pietro
Chimenti, Simona

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http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-81776
DOI (zitierfähiger Link)
https://doi.org/10.1136/hrt.2005.064105
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Biologie: Publikationen
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Published

Erschienen in

Heart. 2006, 92(6), pp. 838-839. ISSN 1355-6037. eISSN 1468-201X. Available under: doi: 10.1136/hrt.2005.064105

Zusammenfassung

In addition to its role as the main regulator of erythropoiesis, erythropoietin has a wide range of protective, antiapoptotic activities in vitro and in vivo, particularly in the brain and, as more recently shown, in the heart.1 Of note, erythropoietin is not exclusively produced by fetal liver and adult kidney but is expressed also in the brain, where it can be induced by hypoxia or ischaemia. Several studies underline the potential role of erythropoietin in mediating hypoxic ischaemic preconditioning in the brain. On the other hand, the heart has never been described as a site for erythropoietin production. However, hypoxia inducible factor 1 (HIF-1), the main transcriptional regulator of erythropoietin, is induced by hypoxia in myocardial cells in vivo and in vitro. HIF-1 has recently been reported to mediate hypoxic preconditioning in the heart. We investigated whether, as in the brain, erythropoietin is produced in mouse ischaemic heart.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

myocardial infarction, ischaemia, erythropoietin

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ISO 690MENGOZZI, M., Renato LATINI, M. SALIO, Alessandra SFACTERIA, G. PIEDIMONTE, Jens GAMMELTOFT GERWIEN, Marcel LEIST, Anna-Leena SIRÉN, Pietro GHEZZI, Simona CHIMENTI, 2006. Increased erythropoietin production after myocardial infarction in mice. In: Heart. 2006, 92(6), pp. 838-839. ISSN 1355-6037. eISSN 1468-201X. Available under: doi: 10.1136/hrt.2005.064105
BibTex
@article{Mengozzi2006Incre-8719,
  year={2006},
  doi={10.1136/hrt.2005.064105},
  title={Increased erythropoietin production after myocardial infarction in mice},
  number={6},
  volume={92},
  issn={1355-6037},
  journal={Heart},
  pages={838--839},
  author={Mengozzi, M. and Latini, Renato and Salio, M. and Sfacteria, Alessandra and Piedimonte, G. and Gammeltoft Gerwien, Jens and Leist, Marcel and Sirén, Anna-Leena and Ghezzi, Pietro and Chimenti, Simona}
}
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