Publikation:

Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor

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diederichs_211543.pdf
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Datum

1991

Autor:innen

Boone, Tom
Karplus, P. Andrew

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-211543
DOI (zitierfähiger Link)
https://doi.org/10.1126/science.1837174
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Biologie: Publikationen
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Published

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Science. 1991, 254(5039), pp. 1779-1782. ISSN 0036-8075. eISSN 1095-9203. Available under: doi: 10.1126/science.1837174

Zusammenfassung

Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates the development of and the cytotoxic activity of white blood cells. Recombinant human GM-CSF has proven useful in the treatment of blood disorders. The structure of GM-CSF, which was determined at 2.4 angstrom resolution by x-ray crystallography, has a novel fold combining a two-stranded antiparallel beta sheet with an open bundle of four alpha helices. Residues implicated in receptor recognition, which are distant in the primary sequence, are on adjacent alpha helices in the folded protein. A working model for the receptor binding site is presented.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

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ISO 690DIEDERICHS, Kay, Tom BOONE, P. Andrew KARPLUS, 1991. Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor. In: Science. 1991, 254(5039), pp. 1779-1782. ISSN 0036-8075. eISSN 1095-9203. Available under: doi: 10.1126/science.1837174
BibTex
@article{Diederichs1991Novel-21154,
  year={1991},
  doi={10.1126/science.1837174},
  title={Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor},
  number={5039},
  volume={254},
  issn={0036-8075},
  journal={Science},
  pages={1779--1782},
  author={Diederichs, Kay and Boone, Tom and Karplus, P. Andrew}
}
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