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Negative Regulation of CD8+ T Cell Function by the IFN-Induced and Double-Stranded RNA-Activated Kinase PKR

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2000

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Xu, Hui
Engeman, Tara M.
Yang, Yi-Li
Fairchild, Robert L.
Williams, Bryan R. G.

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Journal of Immunology. 2000, 165(12), pp. 6896-6901. ISSN 0022-1767. eISSN 1550-6606. Available under: doi: 10.4049/jimmunol.165.12.6896

Zusammenfassung

The IFN-induced and dsRNA-activated kinase (PKR) mediates the antiviral and antiproliferative effects of IFN-α and IFN-γ. Despite these findings, Pkr‾⁄‾ mice have no overt immunological phenotype. Here we tested the role of PKR in llular immunity by determining the induction and elicitation of contact hypersensitivity in Pkr‾⁄‾ mice, a model of T cell-mediated immunity. When compared with wild type, the magnitude of contact hypersensitivity responses in Pkr‾⁄‾ mice were 2-fold higher and of extended duration. This was also observed when naive recipients of immune CD8+ T cells from sensitized Pkr‾⁄‾ and CD4+ T cells from sensitized wild-type Pkr+/+ or Pkr‾⁄‾ mice were challenged with hapten, indicating a regulatory defect intrinsic to the CD8+ T cell population. Isolated lymph node T cells from Pkr‾⁄‾ mice were hyperproliferative during Con A-mediated stimulation. These results implicate PKR for the first time in the growth control of mature T lymphocytes and give insight into the negative regulation of CD8+ T cell-mediated immune responses.

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570 Biowissenschaften, Biologie

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ISO 690KADEREIT, Suzanne, Hui XU, Tara M. ENGEMAN, Yi-Li YANG, Robert L. FAIRCHILD, Bryan R. G. WILLIAMS, 2000. Negative Regulation of CD8+ T Cell Function by the IFN-Induced and Double-Stranded RNA-Activated Kinase PKR. In: Journal of Immunology. 2000, 165(12), pp. 6896-6901. ISSN 0022-1767. eISSN 1550-6606. Available under: doi: 10.4049/jimmunol.165.12.6896
BibTex
@article{Kadereit2000Negat-7807,
  year={2000},
  doi={10.4049/jimmunol.165.12.6896},
  title={Negative Regulation of CD8+ T Cell Function by the IFN-Induced and Double-Stranded RNA-Activated Kinase PKR},
  number={12},
  volume={165},
  issn={0022-1767},
  journal={Journal of Immunology},
  pages={6896--6901},
  author={Kadereit, Suzanne and Xu, Hui and Engeman, Tara M. and Yang, Yi-Li and Fairchild, Robert L. and Williams, Bryan R. G.}
}
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