Monastrol analogs : a synthesis of pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged azolopyrimidine derivatives and their biological screening

Svetlik, Jan; Veizerová, Lucia; Mayer, Thomas U.; Catarinella, Mario

Monastrol analogs : a synthesis of pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged azolopyrimidine derivatives and their biological screening

Dateien

svetlik.pdfGröße: 2.34 MBDownloads: 452

Datum

2010

Autor:innen

Svetlik, Jan

Veizerová, Lucia

Mayer, Thomas U.

Catarinella, Mario

Publikationstyp

Zeitschriftenartikel

unikn.publication.listelement.citation.prefix.version.undefined

Bioorganic & Medicinal Chemistry Letters. 2010, 20(14), pp. 4073-4076. ISSN 0960-894X. eISSN 1464-3405. Available under: doi: 10.1016/j.bmcl.2010.05.085

Zusammenfassung

A synthesis of novel pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged pyrazolo-, tetrazolo-, benzimidazo-, and thiazolopyrimidines via Hantzsch- and Biginelli-like condensations has been developed. The ability of these compounds to inhibit Eg5 activity has been examined. The results indicate that synthetic manipulations in the monastrol thiourea moiety are inefficient.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Biginelli reaction, Hantzsch reaction, Oxygen-bridged nitrogen heterocycles, Monastrol analogs

Zitieren

ISO 690

SVETLIK, Jan, Lucia VEIZEROVÁ, Thomas U. MAYER, Mario CATARINELLA, 2010. Monastrol analogs : a synthesis of pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged azolopyrimidine derivatives and their biological screening. In: Bioorganic & Medicinal Chemistry Letters. 2010, 20(14), pp. 4073-4076. ISSN 0960-894X. eISSN 1464-3405. Available under: doi: 10.1016/j.bmcl.2010.05.085

BibTex

@article{Svetlik2010-07-15Monas-12548,
  year={2010},
  doi={10.1016/j.bmcl.2010.05.085},
  title={Monastrol analogs : a synthesis of pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged azolopyrimidine derivatives and their biological screening},
  number={14},
  volume={20},
  issn={0960-894X},
  journal={Bioorganic & Medicinal Chemistry Letters},
  pages={4073--4076},
  author={Svetlik, Jan and Veizerová, Lucia and Mayer, Thomas U. and Catarinella, Mario}
}

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