Monastrol analogs : a synthesis of pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged azolopyrimidine derivatives and their biological screening

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2010
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Svetlik, Jan
Veizerová, Lucia
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Zusammenfassung

A synthesis of novel pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged pyrazolo-, tetrazolo-, benzimidazo-, and thiazolopyrimidines via Hantzsch- and Biginelli-like condensations has been developed. The ability of these compounds to inhibit Eg5 activity has been examined. The results indicate that synthetic manipulations in the monastrol thiourea moiety are inefficient.

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570 Biowissenschaften, Biologie
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Biginelli reaction, Hantzsch reaction, Oxygen-bridged nitrogen heterocycles, Monastrol analogs
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ISO 690SVETLIK, Jan, Lucia VEIZEROVÁ, Thomas U. MAYER, Mario CATARINELLA, 2010. Monastrol analogs : a synthesis of pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged azolopyrimidine derivatives and their biological screening. In: Bioorganic & Medicinal Chemistry Letters. 2010, 20(14), pp. 4073-4076. ISSN 0960-894X. eISSN 1464-3405. Available under: doi: 10.1016/j.bmcl.2010.05.085
BibTex
@article{Svetlik2010-07-15Monas-12548,
  year={2010},
  doi={10.1016/j.bmcl.2010.05.085},
  title={Monastrol analogs : a synthesis of pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged azolopyrimidine derivatives and their biological screening},
  number={14},
  volume={20},
  issn={0960-894X},
  journal={Bioorganic & Medicinal Chemistry Letters},
  pages={4073--4076},
  author={Svetlik, Jan and Veizerová, Lucia and Mayer, Thomas U. and Catarinella, Mario}
}
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