Publikation: 4-Quinolone N-Oxides as Bacterial Weapons
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2018
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Synlett. 2018, 29(05), pp. 542-547. ISSN 0936-5214. eISSN 1437-2096. Available under: doi: 10.1055/s-0036-1591913
Zusammenfassung
Various bacterial species are known to produce metabolites of the 4-quinolone N-oxide class. These compounds have antibiotic activities, and are believed to target the respiration of competing microbes by interfering with menaquinone-binding sites in enzymes of the electron-transport chain. Interestingly, even minor structural changes in related N-oxides produced by the same organism can produce a dramatic difference in antibiotic activity, suggesting possible functional specialization.
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540 Chemie
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Pseudomonas, Burkholderia, respiratory chain, metabolites, cytochromes, antibiotics
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SZAMOSVARI, David, Thomas BÖTTCHER, 2018. 4-Quinolone N-Oxides as Bacterial Weapons. In: Synlett. 2018, 29(05), pp. 542-547. ISSN 0936-5214. eISSN 1437-2096. Available under: doi: 10.1055/s-0036-1591913BibTex
@article{Szamosvari2018-03-024Quin-41747,
year={2018},
doi={10.1055/s-0036-1591913},
title={4-Quinolone N-Oxides as Bacterial Weapons},
number={05},
volume={29},
issn={0936-5214},
journal={Synlett},
pages={542--547},
author={Szamosvari, David and Böttcher, Thomas}
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<dcterms:abstract xml:lang="eng">Various bacterial species are known to produce metabolites of the 4-quinolone N-oxide class. These compounds have antibiotic activities, and are believed to target the respiration of competing microbes by interfering with menaquinone-binding sites in enzymes of the electron-transport chain. Interestingly, even minor structural changes in related N-oxides produced by the same organism can produce a dramatic difference in antibiotic activity, suggesting possible functional specialization.</dcterms:abstract>
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