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DNA Damage and Radiosensitivity in Blood Cells from Subjects Undergoing 45 Days of Isolation and Confinement : An Explorative Study

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Datum

2022

Autor:innen

Feiveson, Alan H.
Krieger, Stephanie S.
Crucian, Brian E.
Stahn, Alexander C.
Wu, Honglu

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Current Issues in Molecular Biology. MDPI. 2022, 44(2), pp. 654-669. eISSN 1467-3045. Available under: doi: 10.3390/cimb44020046

Zusammenfassung

The effect of confined and isolated experience on astronauts’ health is an important factor to consider for future space exploration missions. The more confined and isolated humans are, the more likely they are to develop negative behavioral or cognitive conditions such as a mood decline, sleep disorder, depression, fatigue and/or physiological problems associated with chronic stress. Molecular mediators of chronic stress, such as cytokines, stress hormones or reactive oxygen species (ROS) are known to induce cellular damage including damage to the DNA. In view of the growing evidence of chronic stress-induced DNA damage, we conducted an explorative study and measured DNA strand breaks in 20 healthy adults. The participants were grouped into five teams (missions). Each team was composed of four participants, who spent 45 days in isolation and confinement in NASA’s Human Exploration Research Analog (HERA). Endogenous DNA integrity, ex-vivo radiation-induced DNA damage and the rates of DNA repair were assessed every week. Our results show a high inter-individual variability as well as differences between the missions, which cannot be explained by inter-individual variability alone. The ages and sex of the participants did not appear to influence the results.

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie

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space environment; stress; DNA damage; radiation

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ISO 690FEIVESON, Alan H., Stephanie S. KRIEGER, Gudrun VON SCHEVEN, Brian E. CRUCIAN, Alexander BÜRKLE, Alexander C. STAHN, Honglu WU, Maria MORENO-VILLANUEVA, 2022. DNA Damage and Radiosensitivity in Blood Cells from Subjects Undergoing 45 Days of Isolation and Confinement : An Explorative Study. In: Current Issues in Molecular Biology. MDPI. 2022, 44(2), pp. 654-669. eISSN 1467-3045. Available under: doi: 10.3390/cimb44020046
BibTex
@article{Feiveson2022-02Damag-56679,
  year={2022},
  doi={10.3390/cimb44020046},
  title={DNA Damage and Radiosensitivity in Blood Cells from Subjects Undergoing 45 Days of Isolation and Confinement : An Explorative Study},
  number={2},
  volume={44},
  journal={Current Issues in Molecular Biology},
  pages={654--669},
  author={Feiveson, Alan H. and Krieger, Stephanie S. and von Scheven, Gudrun and Crucian, Brian E. and Bürkle, Alexander and Stahn, Alexander C. and Wu, Honglu and Moreno-Villanueva, Maria},
  note={German Research Foundation (DFG, Grant No. MO 2243-2-2)}
}
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German Research Foundation (DFG, Grant No. MO 2243-2-2)
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