Long Fluorescence Lifetime Molecular Probes Based on Near Infrared Pyrrolopyrrole Cyanine Fluorophores for In Vivo Imaging

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2009
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Berezin, Mikhail Y.
Akers, Walter J.
Guo, Kevin
Achilefu, Samuel
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Biophysical Journal. 2009, 97(9), pp. L22-L24. ISSN 0006-3495. eISSN 1542-0086. Available under: doi: 10.1016/j.bpj.2009.08.022
Zusammenfassung

Fluorescence lifetime (FLT) properties of organic molecules provide a new reporting strategy for molecular imaging in the near infrared (NIR) spectral region. Unfortunately, most of the NIR fluorescent dyes have short FLT typically clustered below 1.5 ns. In this study, we demonstrate that a new class of NIR fluorescent dyes, pyrrolopyrrole cyanine dyes, have exceptionally long FLTs ranging from 3 to 4 ns, both in vitro (dimethyl sulfoxide and albumin/water solutions) and in vivo (mice). These results provide a new window for imaging molecular processes, rejecting backscattered light and autofluorescence, and multiplexing imaging information with conventional NIR fluorescent dyes that absorb and emit light at similar wavelengths.

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ISO 690BEREZIN, Mikhail Y., Walter J. AKERS, Kevin GUO, Georg FISCHER, Ewald DALTROZZO, Andreas ZUMBUSCH, Samuel ACHILEFU, 2009. Long Fluorescence Lifetime Molecular Probes Based on Near Infrared Pyrrolopyrrole Cyanine Fluorophores for In Vivo Imaging. In: Biophysical Journal. 2009, 97(9), pp. L22-L24. ISSN 0006-3495. eISSN 1542-0086. Available under: doi: 10.1016/j.bpj.2009.08.022
BibTex
@article{Berezin2009-11-04Fluor-1070,
  year={2009},
  doi={10.1016/j.bpj.2009.08.022},
  title={Long Fluorescence Lifetime Molecular Probes Based on Near Infrared Pyrrolopyrrole Cyanine Fluorophores for In Vivo Imaging},
  number={9},
  volume={97},
  issn={0006-3495},
  journal={Biophysical Journal},
  pages={L22--L24},
  author={Berezin, Mikhail Y. and Akers, Walter J. and Guo, Kevin and Fischer, Georg and Daltrozzo, Ewald and Zumbusch, Andreas and Achilefu, Samuel}
}
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