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Target-mediated drug disposition with drug–drug interaction, Part I: single drug case in alternative formulations

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2017

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Jusko, William J.

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https://doi.org/10.1007/s10928-016-9501-1
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Journal of Pharmacokinetics and Pharmacodynamics. 2017, 44(1), pp. 17-26. ISSN 1567-567X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-016-9501-1

Zusammenfassung

Target-mediated drug disposition (TMDD) describes drug binding with high affinity to a target such as a receptor. In application TMDD models are often over-parameterized and quasi-equilibrium (QE) or quasi-steady state (QSS) approximations are essential to reduce the number of parameters. However, implementation of such approximations becomes difficult for TMDD models with drug-drug interaction (DDI) mechanisms. Hence, alternative but equivalent formulations are necessary for QE or QSS approximations. To introduce and develop such formulations, the single drug case is reanalyzed. This work opens the route for straightforward implementation of QE or QSS approximations of DDI TMDD models. The manuscript is the first part to introduce DDI TMDD models with QE or QSS approximations.

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ISO 690KOCH, Gilbert, William J. JUSKO, Johannes SCHROPP, 2017. Target-mediated drug disposition with drug–drug interaction, Part I: single drug case in alternative formulations. In: Journal of Pharmacokinetics and Pharmacodynamics. 2017, 44(1), pp. 17-26. ISSN 1567-567X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-016-9501-1
BibTex
@article{Koch2017-02Targe-38579,
  year={2017},
  doi={10.1007/s10928-016-9501-1},
  title={Target-mediated drug disposition with drug–drug interaction, Part I: single drug case in alternative formulations},
  number={1},
  volume={44},
  issn={1567-567X},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
  pages={17--26},
  author={Koch, Gilbert and Jusko, William J. and Schropp, Johannes}
}
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