Publikation:

CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2

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Scandella_166780.pdf
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2004

Autor:innen

Scandella, Elke
Men, Ying
Gillessen, Silke
Prikler, Ladislav
Ludewig, Burkhard

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http://nbn-resolving.de/urn:nbn:de:bsz:352-166780
DOI (zitierfähiger Link)
https://doi.org/10.1182/blood-2003-05-1643
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Biologie: Publikationen
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Published

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Blood. 2004, 103(5), pp. 1595-1601. ISSN 0006-4971. Available under: doi: 10.1182/blood-2003-05-1643

Zusammenfassung

The control of dendritic cell (DC) migration is pivotal for the initiation of cellular immune responses. When activated with inflammatory stimuli, the chemokine receptor CCR7 is up-regulated on DCs. Activated DCs home to lymphoid organs, where the CCR7 ligands CCL19 and CCL21 are expressed. We previously found that human monocyte-derived DCs (MoDCs) exclusively migrated to CCL19 and CCL21 when matured in the presence of prostaglandin (PG) E2. Because PGE2 did not alter CCR7 cell surface expression, we examined whether PGE2 may exert its effect by coupling CCR7 to signal transduction modules. Indeed, stimulation with CCR7 ligands led to enhanced phosphatidylinositol-3-kinase-mediated phosphorylation of protein kinase B when MoDCs were matured in the presence of PGE2. Moreover, CCL19/CCL21-induced intracellular calcium mobilization in MoDCs occurred only when PGE2 was present during maturation. MoDC migration to CCL19 and CCL21 was dependent on phospholipase C and intracellular calcium flux but not on phosphatidylinositol-3 kinase. Hence, our data provide insight into CCL19/CCL21-triggered signal transduction pathways and identify a novel function for PGE2 in controlling the migration of mature MoDCs by facilitating CCR7 signal transduction.

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570 Biowissenschaften, Biologie

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ISO 690SCANDELLA, Elke, Ying MEN, Daniel F. LEGLER, Silke GILLESSEN, Ladislav PRIKLER, Burkhard LUDEWIG, Marcus GRÖTTRUP, 2004. CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. In: Blood. 2004, 103(5), pp. 1595-1601. ISSN 0006-4971. Available under: doi: 10.1182/blood-2003-05-1643
BibTex
@article{Scandella2004-03-01CCL19-16678,
  year={2004},
  doi={10.1182/blood-2003-05-1643},
  title={CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2},
  number={5},
  volume={103},
  issn={0006-4971},
  journal={Blood},
  pages={1595--1601},
  author={Scandella, Elke and Men, Ying and Legler, Daniel F. and Gillessen, Silke and Prikler, Ladislav and Ludewig, Burkhard and Gröttrup, Marcus}
}
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