Publikation:

Nuclear-mitochondrial crosstalk : on the role of the nuclear receptor Liver Receptor Homolog-1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival and cancer

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2021

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http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1j8zpmn77jj904
DOI (zitierfähiger Link)
https://doi.org/10.1002/iub.2386
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CC BY-NC-ND 4.0

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Open Access-Veröffentlichung
Open Access Hybrid

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Chemie: Publikationen
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IUBMB Life. Wiley. 2021, 73(3), pp. 592-610. eISSN 1521-6551. Available under: doi: 10.1002/iub.2386

Zusammenfassung

Liver receptor homolog-1 (LRH-1, NR5A2) is an orphan nuclear receptor with widespread activities in the regulation of development, stemness, metabolism, steroidogenesis, and proliferation. Many of the LRH-1-regulated processes target the mitochondria and associated activities. While under physiological conditions, a balanced LRH-1 expression and regulation contribute to the maintenance of a physiological equilibrium, deregulation of LRH-1 has been associated with inflammation and cancer. In this review, we discuss the role and mechanism(s) of how LRH-1 regulates metabolic processes, cell survival, and cancer in a nuclear-mitochondrial crosstalk, and evaluate its potential as a pharmacological target.

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570 Biowissenschaften, Biologie

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ISO 690MICHALEK, Svenja, Thomas BRUNNER, 2021. Nuclear-mitochondrial crosstalk : on the role of the nuclear receptor Liver Receptor Homolog-1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival and cancer. In: IUBMB Life. Wiley. 2021, 73(3), pp. 592-610. eISSN 1521-6551. Available under: doi: 10.1002/iub.2386
BibTex
@article{Michalek2021Nucle-50733,
  year={2021},
  doi={10.1002/iub.2386},
  title={Nuclear-mitochondrial crosstalk : on the role of the nuclear receptor Liver Receptor Homolog-1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival and cancer},
  number={3},
  volume={73},
  journal={IUBMB Life},
  pages={592--610},
  author={Michalek, Svenja and Brunner, Thomas}
}
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