Publikation: Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice : the role of nitric oxide
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
D-Galactosamine-sensitized mice challenged with tumor necrosis factor α (TNF) developed severe apoptotic and secondary necrotic liver injury as assessed by histology, measurement of cytosolic DNA fragments and determination of liver-specific enzymes in plasma. Pretreatment of mice with interleukin-1β (IL-1) resulted in elevated levels of nitrite/nitrate in serum and rendered mice insensitive towards TNF toxicity. Pharmacological doses of the nitric oxide (NO) donor sodium nitroprusside (SNP) also conferred complete protection against TNF toxicity, suggesting a possible link between IL-1- and NO-induced protection. However, NO-synthesis inhibition by NG-monomethyl-L-arginine failed to abrogate IL-1-induced tolerance against TNF toxicity. We conclude that IL-1 and NO protect against TNF-induced liver injury through distinct pathways.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
BOHLINGER, Ines, Marcel LEIST, Johannes BARSIG, Stefan UHLIG, Gisa TIEGS, Albrecht WENDEL, 1995. Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice : the role of nitric oxide. In: Toxicology Letters. 1995, 82/83, pp. 227-231. ISSN 0378-4274. Available under: doi: 10.1016/0378-4274(95)03480-3BibTex
@article{Bohlinger1995Toler-7047, year={1995}, doi={10.1016/0378-4274(95)03480-3}, title={Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice : the role of nitric oxide}, volume={82/83}, issn={0378-4274}, journal={Toxicology Letters}, pages={227--231}, author={Bohlinger, Ines and Leist, Marcel and Barsig, Johannes and Uhlig, Stefan and Tiegs, Gisa and Wendel, Albrecht} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/7047"> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:language>eng</dc:language> <dcterms:bibliographicCitation>First publ. in: Toxicology Letters 82/83 (1995), pp. 227-231</dcterms:bibliographicCitation> <dc:format>application/pdf</dc:format> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7047/1/Bohlinger_I_Toxicology_Letters_1995.pdf"/> <dc:creator>Wendel, Albrecht</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:31:06Z</dc:date> <dcterms:title>Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice : the role of nitric oxide</dcterms:title> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:contributor>Uhlig, Stefan</dc:contributor> <dc:creator>Uhlig, Stefan</dc:creator> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:creator>Barsig, Johannes</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Leist, Marcel</dc:creator> <dc:rights>terms-of-use</dc:rights> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7047/1/Bohlinger_I_Toxicology_Letters_1995.pdf"/> <dc:contributor>Bohlinger, Ines</dc:contributor> <dc:creator>Bohlinger, Ines</dc:creator> <dc:contributor>Barsig, Johannes</dc:contributor> <dcterms:issued>1995</dcterms:issued> <dc:contributor>Wendel, Albrecht</dc:contributor> <dc:contributor>Leist, Marcel</dc:contributor> <dcterms:abstract xml:lang="eng">D-Galactosamine-sensitized mice challenged with tumor necrosis factor α (TNF) developed severe apoptotic and secondary necrotic liver injury as assessed by histology, measurement of cytosolic DNA fragments and determination of liver-specific enzymes in plasma. Pretreatment of mice with interleukin-1β (IL-1) resulted in elevated levels of nitrite/nitrate in serum and rendered mice insensitive towards TNF toxicity. Pharmacological doses of the nitric oxide (NO) donor sodium nitroprusside (SNP) also conferred complete protection against TNF toxicity, suggesting a possible link between IL-1- and NO-induced protection. However, NO-synthesis inhibition by NG-monomethyl-L-arginine failed to abrogate IL-1-induced tolerance against TNF toxicity. We conclude that IL-1 and NO protect against TNF-induced liver injury through distinct pathways.</dcterms:abstract> <dc:contributor>Tiegs, Gisa</dc:contributor> <dc:creator>Tiegs, Gisa</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7047"/> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:31:06Z</dcterms:available> </rdf:Description> </rdf:RDF>