Publikation:

Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice : the role of nitric oxide

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Bohlinger_I_Toxicology_Letters_1995.pdf
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Datum

1995

Autor:innen

Bohlinger, Ines
Barsig, Johannes
Uhlig, Stefan
Tiegs, Gisa

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Published

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Toxicology Letters. 1995, 82/83, pp. 227-231. ISSN 0378-4274. Available under: doi: 10.1016/0378-4274(95)03480-3

Zusammenfassung

D-Galactosamine-sensitized mice challenged with tumor necrosis factor α (TNF) developed severe apoptotic and secondary necrotic liver injury as assessed by histology, measurement of cytosolic DNA fragments and determination of liver-specific enzymes in plasma. Pretreatment of mice with interleukin-1β (IL-1) resulted in elevated levels of nitrite/nitrate in serum and rendered mice insensitive towards TNF toxicity. Pharmacological doses of the nitric oxide (NO) donor sodium nitroprusside (SNP) also conferred complete protection against TNF toxicity, suggesting a possible link between IL-1- and NO-induced protection. However, NO-synthesis inhibition by NG-monomethyl-L-arginine failed to abrogate IL-1-induced tolerance against TNF toxicity. We conclude that IL-1 and NO protect against TNF-induced liver injury through distinct pathways.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Interleukin-1, Sodium nitroprusside, Liver injury, Necrosis, Apoptosis, Galactosamine

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ISO 690BOHLINGER, Ines, Marcel LEIST, Johannes BARSIG, Stefan UHLIG, Gisa TIEGS, Albrecht WENDEL, 1995. Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice : the role of nitric oxide. In: Toxicology Letters. 1995, 82/83, pp. 227-231. ISSN 0378-4274. Available under: doi: 10.1016/0378-4274(95)03480-3
BibTex
@article{Bohlinger1995Toler-7047,
  year={1995},
  doi={10.1016/0378-4274(95)03480-3},
  title={Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice : the role of nitric oxide},
  volume={82/83},
  issn={0378-4274},
  journal={Toxicology Letters},
  pages={227--231},
  author={Bohlinger, Ines and Leist, Marcel and Barsig, Johannes and Uhlig, Stefan and Tiegs, Gisa and Wendel, Albrecht}
}
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