Publikation:

Effects of Surface Charge on the Conductance of the Gramicidin Channel

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1979

Autor:innen

Bamberg, Ernst
Läuger, Peter

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Published

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Biochimica et Biophysica Acta. 1979, 552(3), pp. 369-378. ISSN 0005-2736. Available under: doi: 10.1016/0005-2736(79)90181-0

Zusammenfassung

The electric conductance of the cation-permeable gramicidin channel in negatively charged phosphatidylserine membranes hlis been studied. At low electrolyte concentrations the single-channel conductance is much larger in the negatively charged membrane than in a neutral membrane. This enhancement of conductance is in agreement with theoretical expectations, although a complete description of the salt concentration dependence of conductance was not possible. The results of these experiments may be compared with previous studies of a negatively charged gramicidin analog (O-pyromellityl gramicidin). It is found that the electrostatic effect on the conductance is much larger for a neutral channel embedded in a negatively charged lipid than for the negatively charged O-pyromellityl analog (with three charges at the channel mouth) embedded in a neutral lipid.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Surface charge, Conductance, Gramicidin channel

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ISO 690APELL, Hans-Jürgen, Ernst BAMBERG, Peter LÄUGER, 1979. Effects of Surface Charge on the Conductance of the Gramicidin Channel. In: Biochimica et Biophysica Acta. 1979, 552(3), pp. 369-378. ISSN 0005-2736. Available under: doi: 10.1016/0005-2736(79)90181-0
BibTex
@article{Apell1979Effec-8200,
  year={1979},
  doi={10.1016/0005-2736(79)90181-0},
  title={Effects of Surface Charge on the Conductance of the Gramicidin Channel},
  number={3},
  volume={552},
  issn={0005-2736},
  journal={Biochimica et Biophysica Acta},
  pages={369--378},
  author={Apell, Hans-Jürgen and Bamberg, Ernst and Läuger, Peter}
}
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