Publikation: Effects of Surface Charge on the Conductance of the Gramicidin Channel
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The electric conductance of the cation-permeable gramicidin channel in negatively charged phosphatidylserine membranes hlis been studied. At low electrolyte concentrations the single-channel conductance is much larger in the negatively charged membrane than in a neutral membrane. This enhancement of conductance is in agreement with theoretical expectations, although a complete description of the salt concentration dependence of conductance was not possible. The results of these experiments may be compared with previous studies of a negatively charged gramicidin analog (O-pyromellityl gramicidin). It is found that the electrostatic effect on the conductance is much larger for a neutral channel embedded in a negatively charged lipid than for the negatively charged O-pyromellityl analog (with three charges at the channel mouth) embedded in a neutral lipid.
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APELL, Hans-Jürgen, Ernst BAMBERG, Peter LÄUGER, 1979. Effects of Surface Charge on the Conductance of the Gramicidin Channel. In: Biochimica et Biophysica Acta. 1979, 552(3), pp. 369-378. ISSN 0005-2736. Available under: doi: 10.1016/0005-2736(79)90181-0BibTex
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year={1979},
doi={10.1016/0005-2736(79)90181-0},
title={Effects of Surface Charge on the Conductance of the Gramicidin Channel},
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volume={552},
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journal={Biochimica et Biophysica Acta},
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author={Apell, Hans-Jürgen and Bamberg, Ernst and Läuger, Peter}
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