Publikation:

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors : Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

Lade...
Vorschaubild

Dateien

1997_Zhang_Unequal Death in T Helper cell.pdf
1997_Zhang_Unequal Death in T Helper cell.pdfGröße: 260.32 KBDownloads: 341

Datum

1997

Autor:innen

Zhang, Xiaohong
Carter, Laura
Dutton, Richard W.
Rogers, Paul
Bradley, Linda
Sato, Takaaki
Reed, John C.
Green, Douglas
Swain, Susan L.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Journal of Experimental Medicine. 1997, 185(10), pp. 1837-1849. ISSN 0022-1007. Available under: doi: 10.1084/jem.185.10.1837

Zusammenfassung

T helper cell (Th) 1, but not Th2, effectors undergo rapid Fas/Fas ligand (FasL)-mediated, activation-induced cell death upon restimulation with antigen. Unequal apoptosis is also observed without restimulation, after a longer lag period. Both effectors undergo delayed apoptosis induced by a non–Fas-mediated pathway. When Th1 and Th2 effectors are co-cultured, Th2 effectors survive preferentially, suggesting the responsible factor(s) is intrinsic to each population. Both Th1 and Th2 effectors express Fas and FasL, but only Th2 effectors express high levels of FAP-1, a Fas-associated phosphatase that may act to inhibit Fas signaling. The rapid death of Th1 effectors leading to selective Th2 survival provides a novel mechanism for differential regulation of the two subsets.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690ZHANG, Xiaohong, Thomas BRUNNER, Laura CARTER, Richard W. DUTTON, Paul ROGERS, Linda BRADLEY, Takaaki SATO, John C. REED, Douglas GREEN, Susan L. SWAIN, 1997. Unequal Death in T Helper Cell (Th)1 and Th2 Effectors : Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis. In: Journal of Experimental Medicine. 1997, 185(10), pp. 1837-1849. ISSN 0022-1007. Available under: doi: 10.1084/jem.185.10.1837
BibTex
@article{Zhang1997Unequ-14313,
  year={1997},
  doi={10.1084/jem.185.10.1837},
  title={Unequal Death in T Helper Cell (Th)1 and Th2 Effectors : Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis},
  number={10},
  volume={185},
  issn={0022-1007},
  journal={Journal of Experimental Medicine},
  pages={1837--1849},
  author={Zhang, Xiaohong and Brunner, Thomas and Carter, Laura and Dutton, Richard W. and Rogers, Paul and Bradley, Linda and Sato, Takaaki and Reed, John C. and Green, Douglas and Swain, Susan L.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/14313">
    <dc:creator>Carter, Laura</dc:creator>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:contributor>Reed, John C.</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-16T08:04:02Z</dcterms:available>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-16T08:04:02Z</dc:date>
    <dcterms:title>Unequal Death in T Helper Cell (Th)1 and Th2 Effectors : Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis</dcterms:title>
    <dcterms:bibliographicCitation>First publ. in: Journal of Experimental Medicine ; 185 (1997), 10. - pp. 1837-1849</dcterms:bibliographicCitation>
    <dc:creator>Reed, John C.</dc:creator>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Brunner, Thomas</dc:contributor>
    <dc:contributor>Rogers, Paul</dc:contributor>
    <dc:creator>Swain, Susan L.</dc:creator>
    <dc:creator>Zhang, Xiaohong</dc:creator>
    <dc:creator>Brunner, Thomas</dc:creator>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14313/2/1997_Zhang_Unequal%20Death%20in%20T%20Helper%20cell.pdf"/>
    <dc:contributor>Zhang, Xiaohong</dc:contributor>
    <dc:contributor>Sato, Takaaki</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:creator>Green, Douglas</dc:creator>
    <dc:contributor>Swain, Susan L.</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14313/2/1997_Zhang_Unequal%20Death%20in%20T%20Helper%20cell.pdf"/>
    <dc:creator>Dutton, Richard W.</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Sato, Takaaki</dc:creator>
    <dc:contributor>Green, Douglas</dc:contributor>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14313"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:issued>1997</dcterms:issued>
    <dc:contributor>Carter, Laura</dc:contributor>
    <dcterms:abstract xml:lang="eng">T helper cell (Th) 1, but not Th2, effectors undergo rapid Fas/Fas ligand (FasL)-mediated, activation-induced cell death upon restimulation with antigen. Unequal apoptosis is also observed without restimulation, after a longer lag period. Both effectors undergo delayed apoptosis induced by a non–Fas-mediated pathway. When Th1 and Th2 effectors are co-cultured, Th2 effectors survive preferentially, suggesting the responsible factor(s) is intrinsic to each population. Both Th1 and Th2 effectors express Fas and FasL, but only Th2 effectors express high levels of FAP-1, a Fas-associated phosphatase that may act to inhibit Fas signaling. The rapid death of Th1 effectors leading to selective Th2 survival provides a novel mechanism for differential regulation of the two subsets.</dcterms:abstract>
    <dc:creator>Bradley, Linda</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Bradley, Linda</dc:contributor>
    <dc:contributor>Dutton, Richard W.</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Rogers, Paul</dc:creator>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen