Publikation:

Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells

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Schumann_0-366093.pdf
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2010

Autor:innen

Lämmermann, Tim
Bruckner, Markus
Polleux, Julien
Spatz, Joachim P.
Schuler, Gerold
Förster, Reinhold
Lutz, Manfred B.
Sixt, Michael

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http://nbn-resolving.de/urn:nbn:de:bsz:352-0-366093
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https://doi.org/10.1016/j.immuni.2010.04.017
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Immunity. 2010, 32(5), S. 703-713. ISSN 1074-7613. eISSN 1097-4180. Verfügbar unter: doi: 10.1016/j.immuni.2010.04.017

Zusammenfassung

Chemokines orchestrate immune cell trafficking by eliciting either directed or random migration and by activating integrins in order to induce cell adhesion. Analyzing dendritic cell (DC) migration, we showed that these distinct cellular responses depended on the mode of chemokine presentation within tissues. The surface-immobilized form of the chemokine CCL21, the heparan sulfate-anchoring ligand of the CC-chemokine receptor 7 (CCR7), caused random movement of DCs that was confined to the chemokine-presenting surface because it triggered integrin-mediated adhesion. Upon direct contact with CCL21, DCs truncated the anchoring residues of CCL21, thereby releasing it from the solid phase. Soluble CCL21 functionally resembles the second CCR7 ligand, CCL19, which lacks anchoring residues and forms soluble gradients. Both soluble CCR7 ligands triggered chemotactic movement, but not surface adhesion. Adhesive random migration and directional steering cooperate to produce dynamic but spatially restricted locomotion patterns closely resembling the cellular dynamics observed in secondary lymphoid organs.

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570 Biowissenschaften, Biologie

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ISO 690SCHUMANN, Kathrin, Tim LÄMMERMANN, Markus BRUCKNER, Daniel F. LEGLER, Julien POLLEUX, Joachim P. SPATZ, Gerold SCHULER, Reinhold FÖRSTER, Manfred B. LUTZ, Michael SIXT, 2010. Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells. In: Immunity. 2010, 32(5), S. 703-713. ISSN 1074-7613. eISSN 1097-4180. Verfügbar unter: doi: 10.1016/j.immuni.2010.04.017
BibTex
@article{Schumann2010Immob-36602,
  title={Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells},
  year={2010},
  doi={10.1016/j.immuni.2010.04.017},
  number={5},
  volume={32},
  issn={1074-7613},
  journal={Immunity},
  pages={703--713},
  author={Schumann, Kathrin and Lämmermann, Tim and Bruckner, Markus and Legler, Daniel F. and Polleux, Julien and Spatz, Joachim P. and Schuler, Gerold and Förster, Reinhold and Lutz, Manfred B. and Sixt, Michael}
}
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