Publikation:

Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells

Lade...
Vorschaubild

Dateien

Carta_2-1l7xxfyqdb7me0.pdf
Carta_2-1l7xxfyqdb7me0.pdfGröße: 3.13 MBDownloads: 14

Datum

2023

Autor:innen

Carta, Giada
van der Stel, Wanda
Scuric, Emma W. J.
Capinha, Liliana
Bennekou, Susanne Hougaard
Forsby, Anna
Walker, Paul
van de Water, Bob
et al.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Link zur Lizenz

Angaben zur Forschungsförderung

European Union (EU): 681002

Projekt

EUToxRisk21
Open Access-Veröffentlichung
Open Access Hybrid
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Cell Biology and Toxicology. Springer. 2023, 39(6), pp. 3031-3059. ISSN 0742-2091. eISSN 1573-6822. Available under: doi: 10.1007/s10565-023-09816-7

Zusammenfassung

Analysis of the transcriptomic alterations upon chemical challenge, provides in depth mechanistic information on the compound’s toxic mode of action, by revealing specific pathway activation and other transcriptional modulations. Mapping changes in cellular behaviour to chemical insult, facilitates the characterisation of chemical hazard. In this study, we assessed the transcriptional landscape of mitochondrial impairment through the inhibition of the electron transport chain (ETC) in a human renal proximal tubular cell line (RPTEC/TERT1). We identified the unfolded protein response pathway (UPR), particularly the PERK/ATF4 branch as a common cellular response across ETC I, II and III inhibitions. This finding and the specific genes elaborated may aid the identification of mitochondrial liabilities of chemicals in both legacy data and prospective transcriptomic studies.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Mitochondria, In vitro, Renal, Stress pathway, Transcriptomic

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690CARTA, Giada, Wanda VAN DER STEL, Emma W. J. SCURIC, Liliana CAPINHA, Johannes DELP, Susanne Hougaard BENNEKOU, Anna FORSBY, Paul WALKER, Marcel LEIST, Bob VAN DE WATER, 2023. Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells. In: Cell Biology and Toxicology. Springer. 2023, 39(6), pp. 3031-3059. ISSN 0742-2091. eISSN 1573-6822. Available under: doi: 10.1007/s10565-023-09816-7
BibTex
@article{Carta2023-06-23Trans-67523,
  year={2023},
  doi={10.1007/s10565-023-09816-7},
  title={Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells},
  number={6},
  volume={39},
  issn={0742-2091},
  journal={Cell Biology and Toxicology},
  pages={3031--3059},
  author={Carta, Giada and van der Stel, Wanda and Scuric, Emma W. J. and Capinha, Liliana and Delp, Johannes and Bennekou, Susanne Hougaard and Forsby, Anna and Walker, Paul and Leist, Marcel and van de Water, Bob}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/67523">
    <dc:contributor>Delp, Johannes</dc:contributor>
    <dc:contributor>van der Stel, Wanda</dc:contributor>
    <dc:contributor>Bennekou, Susanne Hougaard</dc:contributor>
    <dc:contributor>van de Water, Bob</dc:contributor>
    <dcterms:title>Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells</dcterms:title>
    <dc:contributor>Walker, Paul</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/67523"/>
    <dc:creator>Forsby, Anna</dc:creator>
    <dc:contributor>Capinha, Liliana</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2023-08-08T08:16:03Z</dc:date>
    <dc:creator>Scuric, Emma W. J.</dc:creator>
    <dc:creator>Delp, Johannes</dc:creator>
    <dcterms:abstract>Analysis of the transcriptomic alterations upon chemical challenge, provides in depth mechanistic information on the compound’s toxic mode of action, by revealing specific pathway activation and other transcriptional modulations. Mapping changes in cellular behaviour to chemical insult, facilitates the characterisation of chemical hazard. In this study, we assessed the transcriptional landscape of mitochondrial impairment through the inhibition of the electron transport chain (ETC) in a human renal proximal tubular cell line (RPTEC/TERT1). We identified the unfolded protein response pathway (UPR), particularly the PERK/ATF4 branch as a common cellular response across ETC I, II and III inhibitions. This finding and the specific genes elaborated may aid the identification of mitochondrial liabilities of chemicals in both legacy data and prospective transcriptomic studies.</dcterms:abstract>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/67523/1/Carta_2-1l7xxfyqdb7me0.pdf"/>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/>
    <dc:creator>Carta, Giada</dc:creator>
    <dc:creator>van der Stel, Wanda</dc:creator>
    <dc:creator>Capinha, Liliana</dc:creator>
    <dc:creator>van de Water, Bob</dc:creator>
    <dc:language>eng</dc:language>
    <dc:contributor>Leist, Marcel</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Bennekou, Susanne Hougaard</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Walker, Paul</dc:creator>
    <dcterms:issued>2023-06-23</dcterms:issued>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Scuric, Emma W. J.</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2023-08-08T08:16:03Z</dcterms:available>
    <dc:contributor>Forsby, Anna</dc:contributor>
    <dc:rights>Attribution 4.0 International</dc:rights>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/67523/1/Carta_2-1l7xxfyqdb7me0.pdf"/>
    <dc:creator>Leist, Marcel</dc:creator>
    <dc:contributor>Carta, Giada</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen