Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1

Orth, Barbara; Sander, Bodo; Möglich, Andreas; Diederichs, Kay; Eilers, Martin; Lorenz, Sonja

Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2021

Autor:innen

Orth, Barbara

Sander, Bodo

Möglich, Andreas

Diederichs, Kay

Eilers, Martin

Lorenz, Sonja

DOI (zitierfähiger Link)

https://doi.org/10.1016/j.str.2021.06.005

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Structure. Cell Press. 2021, 29(11), pp. 1230-1240.e5. ISSN 0969-2126. eISSN 1878-4186. Available under: doi: 10.1016/j.str.2021.06.005

Zusammenfassung

The repurposing of structurally conserved protein domains in different functional contexts is thought to be a driving force in the evolution of complex protein interaction networks. The BTB/POZ domain is such a versatile binding module that occurs over 200 times in the human proteome with diverse protein-specific adaptations. In BTB-zinc-finger transcription factors, the BTB domain drives homo- and heterodimerization as well as interactions with non-BTB-domain-containing proteins. Which mechanisms encode specificity in these interactions at a structural level is incompletely understood. Here, we uncover an atypical peptide-binding site in the BTB domain of the MYC-interacting zinc-finger protein 1 (MIZ1) that arises from local flexibility of the core BTB fold and may provide a target site for MIZ1-directed therapeutic approaches. Intriguingly, the identified binding mode requires the BTB domain to be in a homodimeric state, thus holding opportunities for functional discrimination between homo- and heterodimers of MIZ1 in the cell.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

ORTH, Barbara, Bodo SANDER, Andreas MÖGLICH, Kay DIEDERICHS, Martin EILERS, Sonja LORENZ, 2021. Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1. In: Structure. Cell Press. 2021, 29(11), pp. 1230-1240.e5. ISSN 0969-2126. eISSN 1878-4186. Available under: doi: 10.1016/j.str.2021.06.005

BibTex

@article{Orth2021-11-04Ident-54181,
  year={2021},
  doi={10.1016/j.str.2021.06.005},
  title={Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1},
  number={11},
  volume={29},
  issn={0969-2126},
  journal={Structure},
  pages={1230--1240.e5},
  author={Orth, Barbara and Sander, Bodo and Möglich, Andreas and Diederichs, Kay and Eilers, Martin and Lorenz, Sonja}
}

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