Publikation: Derivatives of erythropoietin that are tissue protective but not erythropoietic
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2004
Autor:innen
Ghezzi, Pietro
Grasso, Giovanni
Bianchi, Roberto
Villa, Pia
Fratelli, Maddalena
Savino, Costanza
Bianchi, Marina
Nielsen, Jacob
Gerwien, Jens
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Science. 2004, 305(5681), pp. 239-242. ISSN 0036-8075. eISSN 1095-9203. Available under: doi: 10.1126/science.1098313
Zusammenfassung
Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype–selective ligands allowing the separation of EPO's bioactivities at the cellular level and in animals. Carbamylated EPO (CEPO) or certain EPO mutants did not bind to the classical EPO receptor (EPOR) and did not show any hematopoietic activity in human cell signaling assays or upon chronic dosing in different animal species. Nevertheless, CEPO and various nonhematopoietic mutants were cytoprotective in vitro and conferred neuroprotection against stroke, spinal cord compression, diabetic neuropathy, and experimental autoimmune encephalomyelitis at a potency and efficacy comparable to EPO.
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570 Biowissenschaften, Biologie
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LEIST, Marcel, Pietro GHEZZI, Giovanni GRASSO, Roberto BIANCHI, Pia VILLA, Maddalena FRATELLI, Costanza SAVINO, Marina BIANCHI, Jacob NIELSEN, Jens GERWIEN, Pekka KALLUNKI, 2004. Derivatives of erythropoietin that are tissue protective but not erythropoietic. In: Science. 2004, 305(5681), pp. 239-242. ISSN 0036-8075. eISSN 1095-9203. Available under: doi: 10.1126/science.1098313BibTex
@article{Leist2004-07-09Deriv-20163,
year={2004},
doi={10.1126/science.1098313},
title={Derivatives of erythropoietin that are tissue protective but not erythropoietic},
number={5681},
volume={305},
issn={0036-8075},
journal={Science},
pages={239--242},
author={Leist, Marcel and Ghezzi, Pietro and Grasso, Giovanni and Bianchi, Roberto and Villa, Pia and Fratelli, Maddalena and Savino, Costanza and Bianchi, Marina and Nielsen, Jacob and Gerwien, Jens and Kallunki, Pekka}
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<dcterms:abstract xml:lang="eng">Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype–selective ligands allowing the separation of EPO's bioactivities at the cellular level and in animals. Carbamylated EPO (CEPO) or certain EPO mutants did not bind to the classical EPO receptor (EPOR) and did not show any hematopoietic activity in human cell signaling assays or upon chronic dosing in different animal species. Nevertheless, CEPO and various nonhematopoietic mutants were cytoprotective in vitro and conferred neuroprotection against stroke, spinal cord compression, diabetic neuropathy, and experimental autoimmune encephalomyelitis at a potency and efficacy comparable to EPO.</dcterms:abstract>
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