Publikation:

Ubiquitin, E6-AP, and Their Role in p53 Inactivation

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1998

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Pharmacology & Therapeutics. 1998, 78(3), pp. 129-139. ISSN 0163-7258. eISSN 1879-016X. Available under: doi: 10.1016/S0163-7258(98)00003-5

Zusammenfassung

Inactivation of the tumor suppressor protein p53 plays a key role in human carcinogenesis. Activation of the growth-suppressive properties of p53 by appropriate stress signals, including genotoxic stress, is generally accompanied by intracellular accumulation of the protein. This suggests that stabilization of the otherwise short-lived protein is an intrinsic feature of p53 activation. The ubiquitin/proteasome system is believed to be a major proteolytic system involved in selective degradation of cell regulatory proteins. In this review, the potential role of the ubiquitin/proteasome system in p53 degradation and possible mechanisms involved in p53 stability regulation are discussed.

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie

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Ubiquitin; p53; E6-AP; protein degradation; carcinogenesis

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ISO 690SCHEFFNER, Martin, 1998. Ubiquitin, E6-AP, and Their Role in p53 Inactivation. In: Pharmacology & Therapeutics. 1998, 78(3), pp. 129-139. ISSN 0163-7258. eISSN 1879-016X. Available under: doi: 10.1016/S0163-7258(98)00003-5
BibTex
@article{Scheffner1998Ubiqu-42650,
  year={1998},
  doi={10.1016/S0163-7258(98)00003-5},
  title={Ubiquitin, E6-AP, and Their Role in p53 Inactivation},
  number={3},
  volume={78},
  issn={0163-7258},
  journal={Pharmacology & Therapeutics},
  pages={129--139},
  author={Scheffner, Martin}
}
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