Publikation: Ubiquitin, E6-AP, and Their Role in p53 Inactivation
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1998
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Pharmacology & Therapeutics. 1998, 78(3), pp. 129-139. ISSN 0163-7258. eISSN 1879-016X. Available under: doi: 10.1016/S0163-7258(98)00003-5
Zusammenfassung
Inactivation of the tumor suppressor protein p53 plays a key role in human carcinogenesis. Activation of the growth-suppressive properties of p53 by appropriate stress signals, including genotoxic stress, is generally accompanied by intracellular accumulation of the protein. This suggests that stabilization of the otherwise short-lived protein is an intrinsic feature of p53 activation. The ubiquitin/proteasome system is believed to be a major proteolytic system involved in selective degradation of cell regulatory proteins. In this review, the potential role of the ubiquitin/proteasome system in p53 degradation and possible mechanisms involved in p53 stability regulation are discussed.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
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Ubiquitin; p53; E6-AP; protein degradation; carcinogenesis
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SCHEFFNER, Martin, 1998. Ubiquitin, E6-AP, and Their Role in p53 Inactivation. In: Pharmacology & Therapeutics. 1998, 78(3), pp. 129-139. ISSN 0163-7258. eISSN 1879-016X. Available under: doi: 10.1016/S0163-7258(98)00003-5BibTex
@article{Scheffner1998Ubiqu-42650,
year={1998},
doi={10.1016/S0163-7258(98)00003-5},
title={Ubiquitin, E6-AP, and Their Role in p53 Inactivation},
number={3},
volume={78},
issn={0163-7258},
journal={Pharmacology & Therapeutics},
pages={129--139},
author={Scheffner, Martin}
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